Sökning: "glial cell line-derived neurotrophic factor GDNF"
Visar resultat 1 - 5 av 40 avhandlingar innehållade orden glial cell line-derived neurotrophic factor GDNF.
1. Advancing gene therapy for epilepsy. Translational pre-clinical studies with neuropeptide Y and glial cell-line derived neurotrophic factor
Sammanfattning : Epilepsy is a neurological disorder, affecting approximately 1% of the population. The high rate of drug-resistance in epilepsy in general (30%), and temporal lobe epilepsy (TLE) in particular, pose a serious clinical problem. Thus, novel treatments for drug-resistant epilepsy is highly warranted. LÄS MER
2. Development and preclinical assessment of novel therapies for Epilepsy. Exploring the potential of human-derived cell lines and glial cell line-derived neurotrophic factor for network inhibition
Sammanfattning : Epilepsy is one of the leading neurological disorders affecting not only patients who suffer from seizures but also people around them and society in general. The striking one third of patients not responding to pharmacological treatments implies the necessity of developing alternative options for controlling seizures in these individuals. LÄS MER
3. Glial cell line-derived neurotrophic factor : expression patterns, neuronal transport, regulation, effects, and receptor dependence
Sammanfattning : Background: The mammalian nervous system depends upon trophic proteins for survival, growth and adult maintenance. These trophic factors have also been considered as potential therapeutic agents for treating human neurodegenerative disorders. LÄS MER
4. Restorative and neuroprotective treatment strategies for Parkinson’s disease: tudies on fetal dopamine cell transplants and GDNF delivery by intracerebral injections and recombinant AAV vectors
Sammanfattning : The intrastriatal 6-hydroxydopamine lesion model in rats is particularly useful in studies testing new therapeutic strategies for Parkinson’s disease. This thesis work (1) describes the characterization of the motor deficits after different types of intrastriatal lesions and identifies the four-site terminal lesion as a model of symptomatic Parkinson’s disease; (2) using the same model, provides evidence that the functional impact of the dopamine cell grafts are dependent on interactions with the host brain; (3) demonstrates that protection or restitution of normal motor function after 6-hydroxydopamine lesions can be achieved if glial cell line-derived neurotrophic factor is administered in the striatum at the time of the terminal fiber degeneration. LÄS MER
5. Regeneration of Peripheral Nerves. The role of protein kinases, with emphasis on neurotrophic factor stimulation
Sammanfattning : The purpose of this study was to investigate the role of protein kinases in peripheral nerve regeneration, with the use of dorsal root ganglia (DRG) and nodose ganglia explants from adult mice. The effects of neurotrophic factor stimulation and protein kinase inhibition were studied for long (days) and short term (minutes) effects. LÄS MER