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Visar resultat 1 - 5 av 83 avhandlingar som matchar ovanstående sökkriterier.
1. Glioma as an Ecosystem : Studies of Invasion, Onco-miR Addiction and Mast Cell Infiltration
Sammanfattning : Despite recent advances in oncology and extensive research efforts, gliomas remain essentially incurable. Glioblastoma multiforme (GBM, WHO grade IV) is the most common glioma and may arise de novo or progress from a lower-grade lesion. GBM is characterized by invasive growth, aberrant angiogenesis and necrosis. LÄS MER
2. The role of glial cells in alpha-synuclein pathology : Focus on degradation, cell-to-cell propagation and inflammation
Sammanfattning : Growing evidence emphasizes the role of astrocytes and microglia in Parkinson’s disease (PD) and Alzheimer’s disease (AD). Yet, little is known about their impact on specific disease processes and if their involvement is beneficial or detrimental. LÄS MER
3. The functional organization of nuclear membrane proteins and development of new technology for studies of cell signaling
Sammanfattning : The eukaryotic cell is defined by the nucleus, which is delimited by a double membrane structure termed the nuclear envelope (NE). The NE is implicated in a multitude of different processes, for example chromatin organization. LÄS MER
4. Genetic mechanisms behind cell specification in the Drosophila CNS
Sammanfattning : The human central nervous system (CNS) contains a daunting number of cells and tremendous cellular diversity. A fundamental challenge of developmental neurobiology is to address the questions of how so many different types of neurons and glia can be generated at the precise time and place, making precisely the right connections. LÄS MER
5. Altered cell signaling linked to neurodegeneration : Studies on scrapie-infected neuroblastoma cells and activated microglia
Sammanfattning : Prion diseases are neurodegenerative disorders that can affect humans and animals. The underlying event is a conformational change of the normal cellular prion protein (PrPC) into an aberrant isoform termed PrP-scrapie (PrPSc). PrPSc is thought to lead to neurodegeneration and activation of glial cells. LÄS MER