Sökning: "glia fibrillary acidic protein"
Visar resultat 1 - 5 av 9 avhandlingar innehållade orden glia fibrillary acidic protein.
1. Studies of cerebral blood flow and cerebrospinal fluid in childhood acute lymphoblastic leukemia
Sammanfattning : Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy and more than 80% of the patients are cured today. Treatment might cause side effects and central nervous system (CNS) irradiation has been replaced by systemic high-dose methotrexate (MTX) and intrathecal (IT) MTX due to the risk of late effects. LÄS MER
2. On age related changes in axons and glia of the central nervous system
Sammanfattning : A growing body of evidence shows that phenotypic changes including axon aberrations, rather than loss of neurons, account for behavioral impairments during aging. The present thesis was undertaken to investigate the occurrence of axon aberrations in relation to transmitter identity, glial reaction and sensorimotor disturbances. LÄS MER
3. Photoreceptor degeneration, second order neuron remodeling and glia reactivity in an in vivo and in vitro model of retinal neurodegeneration
Sammanfattning : Photoreceptors have the ability to last during the entire lifespan of an individual. Being the first line of neurons in the visual transduction pathway, their health and maintenance is eminent for proper retinal function. However, photoreceptors are susceptible to neurodegenerative retinal dystrophies. LÄS MER
4. Regulation of neurotrophins and their receptors : molecular aspects and functional implications
Sammanfattning : The aim of this work was to study the regulation of neurotrophins and their receptors in a functional aspect. The studies included analysis of neuronal and glial neurotrophin gene expression, that was investigated by using molecular biological techniques. LÄS MER
5. Role of IL-1RAcP and IL-1ra in IL-1 signalling : molecular biological and transgenic studies
Sammanfattning : IL-1 is a proinflammatory cytokine which causes systemic responses such as fever, increased neuroendocrine activity, sympathetic outflow and increased immune responses. Activation of the transcription factor NFkB is one of the molecular mechanisms involved in IL-1 signalling. LÄS MER