Sökning: "germline stem cell"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden germline stem cell.

  1. 1. Determine the developmental dynamics of primordial follicles in the mouse ovary

    Författare :Wenjing Zheng; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; ovary; primordial follicles; germline stem cell; cell lineage tracing;

    Sammanfattning : Ovarian follicles are the basic functional units of the mammalian ovary. Progressive activation of primordial follicles serves as the source of fertilizable ova. LÄS MER

  3. 2. Developing new models of childhood malignancies using human induced pluripotent stem cells

    Författare :Ana Marin Navarro; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Early onset diseases such as childhood malignancies and neurodevelopmental disorders have been intricate to study. For many years, research has relied and dependent upon different animal systems. LÄS MER

  4. 3. The human ovary : a characterization of cell types and adverse ovarian side effects of chemotherapy

    Författare :Magdalena Wagner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The human ovary has a major role in the body’s endocrine and reproductive system. Understanding its cell type composition is crucial in order to study underlying mechanisms of hormonal balance and ovarian follicle maturation in health and disease. The outer lining of the ovary, the cortex, harbors the ovarian reserve. LÄS MER

  5. 4. Human cytotoxic lymphocyte differentiation in health and disease

    Författare :Heinrich Schlums; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cytotoxic lymphocytes, comprising natural killer (NK) cells and CD8+ cytotoxic T cells, eradicate infected or malignant cells by release of lytic granules and alarm the immune system through production of pro-inflammatory cytokines and chemokines. NK cells and CD8+ T cells belong to different arms of the immune system, employing complementary strategies for target cell recognition. LÄS MER

  7. 5. Genetic studies of susceptibility to inflammation, autoimmunity, and hematological malignancy

    Författare :Bianca Tesi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The immune system represents the body’s defense against infectious organisms. Inborn defects of the immune system, called primary immunodeficiencies (PIDs), are a heterogeneous group of Mendelian disorders. Clinically, PIDs can cause isolated to broad susceptibility to pathogens, severe hyperinflammation, autoimmunity, allergy, and cancer. LÄS MER