Sökning: "germinal centre"

Visar resultat 1 - 5 av 13 avhandlingar innehållade orden germinal centre.

  1. 1. The Germinal Centre reaction - Genetic and proteomic analysis of factors important for survival and growth of B lymphocytes

    Författare :Linda Zander; Göteborgs universitet; []
    Nyckelord :B lymphocyte; germinal centre; transformation; serum-free; MHC class II; bare lymphocyte syndrome; extracellular proteins; DNA repair; Polymerase ?;

    Sammanfattning : During an immune response the B lymphocytes main function is to produce antibodies in the specific defence against the pathogen. When naïve B lymphocytes become activated by binding of an antigen, the cells differentiate to become antibody producing plasma cells. LÄS MER

  3. 2. Cellular and Molecular Aspects of the Germinal Centre Reaction

    Författare :Katarina Dahlenborg; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; serology; Immunology; Biotechnology; Bioteknik; transplantation; Immunologi; serologi;

    Sammanfattning : The humoral immune response to a T cell dependent protein antigen will over time generate antibodies with an increased affinity to the antigen. This is due to a process known as affinity maturation and proceeds in a, for this purpose, well designed micro-milieu within secondary lymphoid organs known as germinal centres. LÄS MER

  4. 3. Life and death of human B cells in health and disease

    Författare :Andy Dernstedt; Mattias N. E. Forsell; Clas Ahlm; Jonas Klingström; Mats Bemark; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; b cells; antibody; hantavirus; germinal centre; phagocytosis; selection; DAF; vaccination; rituximab;

    Sammanfattning : B cells provide one of the key mechanisms of immunological memory, which is theproduction of neutralising antibodies. How B cells respond to infections and vaccinationgives clues to how the development of the immunological memory is facilitated, and canthus lead to a deeper understanding of why the immune system sometimesmalfunctions. LÄS MER

  5. 4. Signalling mechanisms in B cell differentiation: Studies on specific human immune response in vitro

    Författare :Sigurdur Ingvarsson; Institutionen för immunteknologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Bioteknik; Biotechnology; CD44; CD40; Specific antibody secretion; B cells; Germinal centres; serology; transplantation; Immunologi; serologi;

    Sammanfattning : We need to understand the major signalling events in human B cell differentiation in order to be able to regulate the generation of human antigen specific antibodies. This study has focused on the signalling mechanisms involved in generation of germinal centre reaction and secretion of specific antibodies by human B cells, using different in vitro immunisation technologies. LÄS MER

  7. 5. Associations Between Rheumatoid Arthritis and Malignant Lymphomas

    Författare :Eva Baecklund; Christer Sundström; Anders Ekbom; Roger Hällgren; Tore Kvien; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine; rheumatoid arthritis; malignant lymphoma; diffuse large B-cell lymphoma; disease activity; disease modifying anti-rheumatic drug; Epstein-Barr virus; germinal centre-like non-germinal centre-like subtype; Medicin; Dermatology and venerology; clinical genetics; internal medicine; Dermatologi och venerologi; klinisk genetik; invärtesmedicin;

    Sammanfattning : Patients with rheumatoid arthritis (RA) are at increased risk of developing malignant lymphoma, although details about this association remain unclear. The aims of this thesis were to investigate risk factors for lymphoma in patients with RA and to characterize these lymphomas regarding subtype, presence of Epstein-Barr virus (EBV), clinical manifestations and prognosis. LÄS MER