Sökning: "genotyping technology"

Visar resultat 21 - 25 av 38 avhandlingar innehållade orden genotyping technology.

  1. 21. Statistical Modeling and Learning of the Environmental and Genetic Drivers of Variation in Human Immunity

    Författare :Jacob Bergstedt; Institutionen för reglerteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY;

    Sammanfattning : During the last decade the variation in the human genome has been mapped in fine detail. Next generation sequencing has made it possible to cheaply and rapidly aquire vast amounts of biomolecular information on large cohorts of people. LÄS MER

  3. 22. Using Minisequencing Technology for Analysing Genetic Variation in DNA and RNA

    Författare :Mona Fredriksson; Ann-Christine Syvänen; Aarno Palotie; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Molecular medicine; microarray; minisequencing; molecular medicine; single nucleotide polymorphism; stem cell transplantation; whole genome amplification; allelic imbalance; alternative splicing; Molekylärmedicin; Molecular medicine genetics and pathology ; Molekylär medicin genetik och patologi ;

    Sammanfattning : In this thesis, the four-color fluorescence tag-microarray minisequencing system pioneered by our group was further developed and applied for analysing genetic variation in human DNA and RNA. A SNP marker panel representing different chromosomal regions was established and used for identification of informative SNP markers for monitoring chimerism after stem cell transplantation (SCT). LÄS MER

  4. 23. Correlated selection responses in animal domestication : the behavioural effects of a growth QTL in chickens

    Författare :Anders Wirén; Per Jensen; Elena Jazin; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Studying animal domestication offers an opportunity to understand the mechanisms of evolution. Domestication is associated with a change in selection pressures; selection for production traits is introduced, and animals are faced with larger and denser social groups. LÄS MER

  5. 24. Biophysical Characterization of Thiopurine S-Methyltransferase : A Key enzyme in the Effects of Thiopurine Drugs

    Författare :Patricia Wennerstrand; Lars-Göran Mårtensson; Curt Peterson; Malin Lindqvist Appell; Mikael Widersten; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : In the treatment of leukemia and inflammatory bowel disease, thiopurines are commonly used drugs. Thiopurine S-methyltransferase (TPMT) is one of the drug metabolizing enzymes responsible of counteracting the formation of TGNs that will be incorporated into the DNA and RNA synthesis and thus induce apoptosis. LÄS MER

  7. 25. Computational exploration of human genome variation

    Författare :David Fredman; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :SNP; polymorphism; database; genotyping; duplication; haplotype;

    Sammanfattning : In studies of human genome variation, researchers attempt to identify the DNA sequence differences between our genomes that contribute substantially to variation that can be observed on a physical level (phenotype). Genetic variation can also be used to study population dynamics in human history, and how evolutionary forces have shaped the human genome. LÄS MER