Sökning: "genotyp"

Visar resultat 1 - 5 av 22 avhandlingar innehållade ordet genotyp.

  1. 1. Identification of new disease mechanisms and treatments for type 2 diabetes based on genetic variants and gene expression networks

    Författare :Annika Axelsson; Diabetes - öpatofysiologi; []
    Nyckelord :Type 2 diabetes; insulin; ADRA2A; genotype; gene network analysis; SOX5; drug repositioning; sulforaphane; clinical study; typ 2-diabetes; insulin; ADRA2A; genotyp; gennätverksanalys; SOX5; sulforafan; klinisk studie;

    Sammanfattning : Improved understanding of the disease mechanisms underlying type 2 diabetes (T2D) is needed, and so are new treatments.A new T2D risk variant was recently identified in ADRA2A, which encodes the α2A-adrenergic receptor. LÄS MER

  3. 2. Genetic Factors Contributing to Hypertension. With Emphasis on Hypertension in Type 2 Diabetes

    Författare :Kristina Bengtsson Boström; diabetes och endokrinologi Genomik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endokrinologi; sekretion; diabetologi; Endocrinology; secreting systems; diabetology; primary care; genetics; Hypertension; type 2 diabetes;

    Sammanfattning : The causes of hypertension (HT) and type 2 diabetes (T2DM) are mainly unknown, but they arise from interplay between several genetic and environmental factors. The aim of this thesis was to investigate whether polymorphisms in putative candidate genes for HT increase the susceptibility to HT and/or T2DM. LÄS MER

  4. 3. Genetic, environmental and life-style effects on androgen receptor function

    Författare :Christel Björk; Malmö Molekylärgenetisk reproduktionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; reproductive function; smoking; 4 .4-DDE; persistent organic pollutants; prostate cancer; Androgen receptor; prostate specific antigen; CAG polymorphism; TCDD; aryl hydrocarbon receptor; CB-153;

    Sammanfattning : Androgens regulate male reproductive function and their effects are mediated through the androgen receptor (AR). The AR gene contains a polymorphic CAG repeat, encoding a stretch of glutamines, affecting the transcriptional activity of the AR. LÄS MER

  5. 4. The spatial structure of genetic and morphometric variation in Corylus avellana (Betulaceae): pattern and scale

    Författare :Helena Persson; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; phytogeography; chemotaxonomy. Physiology of nonvascular plants; Systematisk botanik; taxonomi; morfologi; kemotaxonomi. Växters fysiologi inte kärlväxter .; taxonomy; morphology; Systematic botany; Öland; clonal structure; marginal and central populations; image analysis; aerial photographs; morphometric variation; allozymes; Corylus avellana; genetic variation;

    Sammanfattning : In the present thesis, I investigated the spatial structure of genetic and morphometric variation in the widespread wind-pollinated shrub Corylus avellana (L.) Betulaceae, hazel, and related the variation to geographic distribution and different spatial scales. LÄS MER

  7. 5. On the Extraction of Essential Oils by Supercritical Carbon Dioxide and its Influence on the Mesomorphic Phase Structures

    Författare :José da Cruz Francisco; Kemiska institutionen; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Natural oils; fats and waxes technology; Naturliga oljor; fetter; vax; Kemiteknik och kemisk teknologi; Chemical technology and engineering; Livsmedelsteknik; Food and drink technology; phase behavior; soybean lecithin; monoolein; cineole; terpenes; eucalyptus; extraction; Essential oils; supercritical carbon dioxide;

    Sammanfattning : A comparison of essential oils from leaves of Eucalyptus camaldulensis Dehn. obtained by hydrodistillation (HD) and supercritical carbon dioxide (SC-CO2) extraction is presented. Selected major components of the oils showed a predominance of higher molecular weight components in the SC-CO2 extracts than in those obtained by HD. LÄS MER