Sökning: "genotoxicity"

Visar resultat 11 - 15 av 36 avhandlingar innehållade ordet genotoxicity.

1. 11. DNA adducts formed by ethene and butadiene : quantitative analysis in rats and humans

   Författare :Chunyan Zhao; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :DNA adducts; 32P-postlabelling; cancer; genotoxicity; ethene; ethylene oxide; 1; 3-butadiene; epoxybutanediol;

   Sammanfattning : The present study has focused on DNA adduct formation by two important industrial and environmental chemicals, ethene and butadiene, in rats and humans. Ethene and butadiene are among the 50 chemicals produced in greatest volume in the United States. LÄS MER

3. 12. Quantitative analysis of DNA adducts formed by some epoxides of industrial importance

   Författare :Kamila Plná; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :DNA adducts; 32P-postlabelling; cancer; genotoxicity; occupational; epoxides; allyl glycidyl ether; propylene oxide; epichlorohydrin;

   Sammanfattning : The work presented herein has focused on DNA adduct formation by three industrial epoxides, allyl glycidyl ether, propylene oxide and epichlorohydrin. Epoxides, owing to the strained oxirane ring are chemically reactive and can alkylate various sites in DNA. LÄS MER

4. 13. Analysis of DNA adducts formed by tamoxifen and related antiestrogenic and estrogenic compounds in rats

   Författare :Heli Rajaniemi; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :DNA adducts; 32P-postlabelling; tamoxifen; toremifene; diethylstilbestrol; clomiphene; triparanol; raloxifene; antiestrogen; estrogen; SERM; genotoxicity; cancer;

   Sammanfattning : The work presented herein has focused on DNA adduct formation by the non-steroidal antiestrogen tamoxifen and its analogues. Tamoxifen, [(Z)-1-{4-[2-(dimethylamino)-ethoxy]phenyl}-1,2-diphenyl-1-butene], is widely used in the treatment of breast cancer and its recognised side effect is endometrial cancer. LÄS MER

5. 14. Cellular effects of nickel and nickel oxide nanoparticles : focus on mechanisms related to carcinogenicity

   Författare :Emma Åkerlund; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : There has been a rapid increase in the production and useage of nanomaterials during the last decade and therefore it is of great importance to properly investigate safety of these materials. This thesis specifically focuses on nickel (Ni) and nickel oxide (NiO) nanoparticles (NPs). LÄS MER

7. 15. Genotoxic effects of systemic chemotherapy in cancer patients, with special focus on the relation between MSI, LOH and development of secondary cancers

   Författare :Nasir K. Kamat; Ulf Rannug; Giovanni Corso; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemotherapy; Genetic instability; Microsatellites instability; Loss of heterozygosity; Mismatch repair; molekylärgenetik; Molecular Genetics;

   Sammanfattning : Systemic chemotherapy results in both phenotypic and genotypic side effects. Genotoxicity posed by chemotherapy is a major concern since it induces DNA damage and instability in the patients’ genome. LÄS MER