Sökning: "genotoxic exposure"

Visar resultat 1 - 5 av 38 avhandlingar innehållade orden genotoxic exposure.

  1. 1. Biomarkers of internal exposure/dose : Methods to quantify adducts to protein and DNA by LC/MS studied with benzo[a]pyrene and isocyanates

    Författare :Emelie Westberg; Margareta Törnqvist; Kimmo Peltonen; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biomarker; PAH; serum albumin; adduct; DNA; isocyanate; miljökemi; Environmental Chemistry;

    Sammanfattning : This thesis focuses on methods for quantification by liquid chromatography/mass spectrometry (LC/MS) of specific biomarkers for internal dose of chemicals which induce toxicity through their electrophilic reactivity. In vivo such compounds are short-lived, and could feasibly be measured as their reaction products (adducts) with biomacromolecules. LÄS MER

  3. 2. Health of municipal sewage workers : Studies of cancer incidence, biomarkers of carcinogenicity and genotoxicity, and self reported symptoms

    Författare :Lennart Friis; Uppsala universitet; []
    Nyckelord :Medical sciences; Abdominal symptoms; alkaline single cell gel assay; asthma; cancer; comet assay; dyspepsia; genotoxic exposure; Helicobacter pylori; IBS; occupational epidemiology; respiratory symptoms; sewage workers; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; arbets- och miljömedicin; Occupational and Environmental Medicine;

    Sammanfattning : The occupational exposures of sewage workers are complex and variable, and include a great variety of biological and chemical agents. Previous research has focused mostly on infections and various symptoms among sewage workers, e.g. abdominal and respiratory symptoms. LÄS MER

  4. 3. ³²P-postlabelling analysis of DNA adducts in fish as a biomarker of genotoxic exposure

    Författare :Gunilla Ericson; Tracy K Collier; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; zoologisk ekologi; Animal Ecology;

    Sammanfattning : The 32P-postlabelling assay was used for analysis of hydrophobic DNA adducts in fish as a biomarker of genotoxic exposure. DNA adducts were analysed in perch (Perca fluviatilis) and northern pike (Esox lucius), two relatively stationary fish species which are common in Swedish freshwater systems and along the Baltic coast. LÄS MER

  5. 4. Methodology for hemoglobin adduct measurement : Fetal exposures to acrylamide and other genotoxic agents

    Författare :Hans von Stedingk; Margareta Törnqvist; Per Rydberg; Christian Lindh; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; miljökemi; Environmental Chemistry;

    Sammanfattning : There is increasing evidence that exposure to toxic chemicals during the prenatal period constitute a higher health risk than exposure during adulthood. To characterize exposure and identify risk factors, sensitive methods for analysis of chemicals in vivo with biomarker methods are needed. LÄS MER

  7. 5. Cancer Risk Assessment of Glycidol : Evaluation of a Multiplicative Risk Model for Genotoxic Compounds

    Författare :Jenny Aasa; Margareta Törnqvist; Elaine M. Faustman; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; glycidol; 3-monochloropropane-1; 2-diol 3-MCPD ; genotoxicity; mutations; micronuclei; hemoglobin adducts; in vivo dose; multiplicative risk model; cancer risk assessment; human cancer risk; miljökemi; Environmental Chemistry;

    Sammanfattning : Humans are exposed to chemical compounds in everyday life, both from the environment and from endogenous processes. Some compounds constitute a risk for cancer development. One such compound is glycidol, which is genotoxic and an animal carcinogen. It is the model compound of this work, partly due to its presence in food. LÄS MER