Sökning: "genomic typing"

Visar resultat 6 - 10 av 20 avhandlingar innehållade orden genomic typing.

  1. 6. The genetic composition and diversity of Francisella tularensis

    Författare :Pär Larsson; Anders Sjöstedt; Andrew K. Benson; Umeå universitet; []
    Nyckelord :Microbiology; tularemia; genotyping; evolution; microarray; genome sequencing; virulence; genome reduction; Mikrobiologi; Francisella tularensis; klinisk bakteriologi; Clinical Bacteriology;

    Sammanfattning : Francisella tularensis is the causative agent of the debilitating, sometimes fatal zoonotic disease tularemia. To date, little information has been available on the genetic makeup of this pathogen, its evolution, and the genetic differences which characterize subspecific lineages. These are the main areas addressed in this thesis. LÄS MER

  3. 7. HLA and KIR gene polymorphism in hematopoietic stem cell transplantation

    Författare :Marie Schaffer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HLA; KIR; NK cells; hematopoietic stem cell transplantation; unrelated donor;

    Sammanfattning : The major histocompatibility complex (MHC) in humans known as the Human Leukocyte Antigens (HLA) is localised to the short arm of chromosome six. The HLA class 1 antigens, HLA-A, -B and -C are highly polymorphic glycoproteins expressed on the cell surface of most nucleated cells in the body. LÄS MER

  4. 8. Genetic Characterisation of Human ABO Blood Group Variants with a Focus on Subgroups and Hybrid Alleles

    Författare :Bahram Hosseini Maaf; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glycosyltransferase; SNP; computer modelling; ABO genotyping; Immunology; serology; hybrid; Blood group ABO; transplantation; subgroup; Immunologi; serologi; rare O allele;

    Sammanfattning : ABO is the most important blood group system in transfusion medicine and transplantation immunology. The ABO blood groups differ by the presence or absence of antigens on RBCs and antibodies in plasma. Accurate determination of ABO status is critical. Genomic typing can increase the precision of blood group determination in complicated cases, e. LÄS MER

  5. 9. Approaches for analysis of mutations and genetic variations

    Författare :Afshin Ahmadian; KTH; []
    Nyckelord :LOH; microsatellite; fragment analysis; DNA sequencing; pyrosequencing; cancer; mutation; variation; SNP; allele-specific extension; apyrase; TECHNOLOGY; TEKNIKVETENSKAP;

    Sammanfattning : Detecting mutations and genomic variations is fundamental indiagnosis, isolating disease genes, association studies,functional genomics and pharmacogenomics. The objective hasbeen to use and further develop a variety of tools andtechnologies to analyze these genetic alterations andvariations. LÄS MER

  7. 10. A clinical and experimental study of basal cell carcinoma : aspects on epidemiology, genetics and microphysiology

    Författare :Peter Wallberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Basal cell carcinoma; multiple basal cell carcinoma; HLA; X-ray microanalysis; incidence sequence specific primers; PCR;

    Sammanfattning : In the present thesis we report on basal cell carcinoma from the points of view of its incidence, risk factors and pathogenesis, with special interest in patients with more than one basal cell carcinoma in life. Incidence was studied for southern Stockholm during two periods separated by two decades, 1971-1980 and 1996-1997. LÄS MER