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Visar resultat 1 - 5 av 20 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Correlation Between Phenotype and Genotype in Some Clinically Important Blood group Systems

    Författare :Nidal Irshaid; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunologi; transplantation; serology; transfusion medicine; Blood group; DNA; Immunology; genomic typing; serologi;

    Sammanfattning : In the past decade, the molecular basis for most of the blood group systems has been investigated intensively. Many blood group genes have been cloned and the polymorphisms of clinically significant blood group systems have been elucidated. LÄS MER

  3. 2. HLA polymorphism : genomic typing and impact on unrelated stem cell transplantation

    Författare :Anna Aldener-Cannavá; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The HLA (Human Leukocyte Antigen) region is the most polymorphic in the human genome. The extended polymorphism contributes to the ability both of individuals and populations to combat diversity in the pathogens to which they are exposed. LÄS MER

  4. 3. Improved human papillomavirus DNA typing methods and biology of cervival cancer

    Författare :Biying Zheng; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cervical cancer; human papillomavirus; Pyrosequencing; chemokine receptors; adenoassociated virus; biomarkers; and cell cycle checkpoint.;

    Sammanfattning : Cervical cancer is the second most common cancer among women worldwide. Persistent HPV has been identified as a main risk factor in cervical cancer development. Oncoproteins E6 and E7 of highrisk HPV interact with cellular proteins, subverting cell cycle checkpoint, inducing carcinogenesis. LÄS MER

  5. 4. The use of molecular techniques for identification of genetic divergence in transplantation : with special reference to MHC genes and HLA typing

    Författare :Henrik Zetterquist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Clinical transplantation; HLA; histocompatibility testing; PCR; allele-specific amplification; sequence-specific primers; bone marrow transplantation; mixed chimerism; minimal residual disease; acute lymphoblastic leukemia;

    Sammanfattning : Transplantation immunology basically deals with the immune mechanisms that lead to rejection of transplanted tissues. Lymphocytes are the key mediators of graft rejection. At the time for this observation, the genetic loci responsible for histocompatibility between individuals of the same species were already identified in the mouse. LÄS MER

  7. 5. Human leukocyte antigens with special reference to association and linkage in multiple sclerosis

    Författare :Anna Fogdell-Hahn; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HLA; MHC; multiple sclerosis; narcolepsy; lod score; linkage.;

    Sammanfattning : The polymorphism of HLA (human leukocyte antigen) is extensive. Allelic variation has previously been detected by cellular and serological methods. Today a variety of genomic typing techniques have been developed, which give higher resolution and a possibility to detect single nucleotide variations. LÄS MER