Sökning: "genome"
Visar resultat 16 - 20 av 1780 avhandlingar innehållade ordet genome.
16. BEN-solo proteins in genome architecture and function
Sammanfattning : Eukaryotic genomes are organized in a complex manner inside the nucleus of each cell. Chromatin insulators are DNA elements that help to fold the linear DNA fiber in three-dimensional space and partition regulatory gene units. LÄS MER
17. Genome-Wide Studies of Transcriptional Regulation in Mammalian Cells
Sammanfattning : The key to the complexity of higher organisms lies not in the number of protein coding genes they carry, but rather in the intrinsic complexity of the gene regulatory networks. The major effectors of transcriptional regulation are proteins called transcription factors, and in this thesis four papers describing genome-wide studies of seven such factors are presented, together with studies on components of the chromatin and transcriptome. LÄS MER
18. Antibiotic resistance in the pan-genome of E. coli
Sammanfattning : The pan-genome of a species is made up of all gene families that can be included in any individual isolate of the species. Escherichia coli (E. coli) has an open pan-genome including at least 128000 gene families, while only about half of the genes found in each individual isolate are common to all isolates. LÄS MER
19. From protein production to genome evolution in Escherichia coli
Sammanfattning : The aim of my Ph.D. studies was to improve production yields of membrane- and secretory proteins in the widely used E. coli protein production strain BL21(DE3). LÄS MER
20. Whole Genome Sequencing of Enterotoxigenic Escherichia coli
Sammanfattning : Enterotoxigenic Escherichia coli (ETEC) infections are a common cause of diarrhea but little is known about the evolution and genomic composition of ETEC. The main aim of this thesis was to generate a large collection of whole genome sequenced ETEC isolates to study the evolution of such bacteria on a global level and to search for novel colonization factors (CFs) using both classical and cutting-edge genomic techniques. LÄS MER