Sökning: "genome-wide association study"
Visar resultat 21 - 25 av 160 avhandlingar innehållade orden genome-wide association study.
21. Genetics of complications in patients with type 2 diabetes
Sammanfattning : Type 2 diabetes (T2D) is a polygenic disease caused by an interaction between genetic and environmental factors such as low physical activity, smoking, and obesity. The disease is associated with devastating chronic microvascular (nephropathy, retinopathy, and neuropathy) and macrovascular (coronary heart disease and stroke) complications. LÄS MER
22. Integrating bioinformatics and physiology to describe genetic effects in complex polygenic diseases
Sammanfattning : Type 2 diabetes mellitus (T2DM) results from interaction between genetic and environmental factors. The worldwide prevalence of T2DM is increasing rapidly due to reduction in physical activity, increase in dietary intake, and the aging of the population. LÄS MER
23. Use of data mining and artificial intelligence to derive public health evidence from large datasets
Sammanfattning : This thesis explores the use of data mining and AI-tailored frameworks for extracting public health evidence from large health datasets. The research presented in this thesis demonstrates the potential of these tools for automating and simplifying the data mining process, and for providing valuable insights into various public health issues. LÄS MER
24. Genome wide analysis of the Ssn6-Tup11/Tup12 co-repressor complex in the fission yeast Schizosaccharomyces pombe
Sammanfattning : In this study, we have investigated the fission yeast Ssn6-Tup11 /Tup 12 transcriptional corepressor which is involved in regulation of many genes important for a wide variety of processes. In contrast to the well characterised budding yeast Tup1 protein there are two paralogous proteins present in fission yeast, namely Tup11 and Tup12. LÄS MER
25. Analysis of genetic susceptibility to cervical cancer using candidate gene and GWAS approaches
Sammanfattning : Cervical cancer is the forth most commonly diagnosed cancer among women worldwide. It is caused by persistent infection with an oncogenic type of Human Papillomavirus (HPV). The HPV is a necessary but not sufficient cause of cervical cancer. LÄS MER