Sökning: "genome-scale metabolic models"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden genome-scale metabolic models.

  1. 1. On metabolic networks and multi-omics integration

    Författare :Rasmus Ågren; [2013]
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; succinate; genome-scale metabolic model; metabolic engineering; systems biology; penicillin; NASH; flux balance analysis; metabolism; cancer; reconstruction;

    Sammanfattning : Cellular metabolism is a highly complex chemical system, involving thousands of interacting metabolites and reactions. The traditional approach to understanding metabolism has been that of reductionism; by isolating and carefully measuring the involved components, the goal has been to understand the whole as the sum of its parts. LÄS MER

  2. 2. Metabolic Modeling of the Gut Microbiome-Host Interactions and Meta’omics Integration

    Författare :Saeed Shoaie; [2015]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; meta’omics; complexity; obesity; network topology; Gut microbiome; genome-scale metabolic model; gene richness; CASINO; systems biology; flux balance analysis; diabetes;

    Sammanfattning : A large number of microbes with different strain types occupy the human gut. These gut inhabitant microbes have key roles in decomposition of indigestible dietary macronutrients before they are metabolised by the host. LÄS MER

  3. 3. In silico analysis of microbial communities through constraint-based metabolic modelling

    Detta är en avhandling från Gothenburg : Chalmers tekniska högskola

    Författare :Parizad Babaei; [2019]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; fermented food production; metagenomics; genome-scale metabolic model; community modelling; malnourishment; Microbial community; systems biology; lactic acid bacteria; gut microbiota; uniform randomised sampling;

    Sammanfattning : Microbial communities are involved in many vital biological processes from elemental cycles to sustaining human health. The bacterial assemblages are remarkably under-studied as they are reluctant to grow in the laboratory conditions. LÄS MER

  4. 4. Heterogeneity of human metabolism in health and disease: a modelling perspective

    Detta är en avhandling från Gothenburg : Chalmers tekniska högskola

    Författare :Pouyan Ghaffari Nouran; [2017]
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer metabolism; fatty acid metabolism; genome-scale metabolic models; community modeling; heterogeneity; lung cancer; amino acids metabolism; gut microbiome;

    Sammanfattning : Metabolism is broadly defined as the sum of biochemical reactions within cells that are involved in maintaining the living state of the organism. Profound importance of metabolism comes from the fact that it is the sole source of energy that allows life to resist to be degraded into entropy. LÄS MER

  5. 5. Macroscopic models of Chinese hamster ovary cell cultures

    Detta är en avhandling från Gothenburg : Chalmers tekniska högskola

    Författare :Erika Hagrot; Véronique Chotteau; Anders Forsgren; Nathan E. Lewis; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Chinese hamster ovary; Amino acid; Metabolic network; Metabolic flux analysis; Kinetic modeling; Elementary flux mode; Optimization; Column generation; Biotechnology; Bioteknologi;

    Sammanfattning : Biopharmaceuticals treat a range of diseases, and is a growing sector within the pharmaceutical industry. A majority of these complex molecules are produced by genetically modified mammalian cells in large-scale cell cultures. LÄS MER