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Visar resultat 1 - 5 av 22 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Development of novel immunization approaches to generate immunity in the female genital tract with special reference to genital herpes

    Författare :Sara Tengvall; Göteborgs universitet; []
    Nyckelord :female genital tract immunity; genital herpes; mucosal adjuvant; TLR; MyD88; CpG ODN;

    Sammanfattning : Development of mucosal vaccines for inducing immunity in the female reproductive tract would have profound implications for the prevention of sexually transmitted diseases. Despite numerous efforts, no such vaccines are currently available for human use. LÄS MER

  3. 2. Antibody responses in genital secretions and serum after mucosal vaccination in humans

    Författare :Lotta Wassén; Göteborgs universitet; []
    Nyckelord :genital immunity; antibodies; mucosal vaccination; cervical secretions; vaginal fluids;

    Sammanfattning : The overall aim of this thesis was to study the induction of B-cell immune responses in genital secretion and serum after mucosal vaccination in women. Oral inactivated B subunit whole-cell (B-WC) cholera vaccine and recombinant cholera toxin B subunit (CTB) alone were used as model immunogens. LÄS MER

  4. 3. Innate and adaptive immunity in genital HSV-2 infection: Implications for vaccine development

    Författare :Ali M Harandi; Göteborgs universitet; []
    Nyckelord :genital herpes infection; natural antibody; CD4 T cells; CD8 T cells; IFN-g; IL-12; IL-18; CC chemokines; dendritic cells.;

    Sammanfattning : Herpes simplex virus type 2 (HSV-2) is a sexually transmitted pathogen that infects the genital tract mucosa and is the most common case of genital ulcers in humans. Despite numerous studies, little is known about the mechanisms involved in immune protection and no anti-herpes vaccine has been developed to date. LÄS MER

  5. 4. Genital tract CD4+ T cells for vaccination and protection against Chlamydia trachomatis

    Författare :Ellen Marks; Göteborgs universitet; []
    Nyckelord :Chlamydia; T cell differentiation; genital tract; vaccination; costimulation; Th1; Th2; Th17; Tregs;

    Sammanfattning : Vaccination strategies for protection against sexually transmitted diseases (STDs) are lacking due to an incomplete understanding of genital tract T cell responses. This thesis dissects the generation of T helper subsets, including the recently discovered Th17 subset, during genital tract infection with a common sexually transmitted pathogen, Chlamydia trachomatis, and addresses vaccine requirements for the generation of genital tract CD4+ T cell immunity. LÄS MER

  7. 5. Mucosal adjuvants and their mode of action in the female genital tract

    Författare :Madelene Lindqvist; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; immunology; mucosal adjuvants; genital tract; vaccine; HSV-2; mouse; alpha-galactosylceramid; CpG ODN; proteoliposome-derived cochleate; inflammation; bioinformatics;

    Sammanfattning : Sexually transmitted infections (STIs) cause a socioeconomic burden, morbidity and even mortality in a large part of the human population all over the world today. One of the most common genital ulcerative diseases is caused by herpes simplex virus type 2 with over 536 million people infected world-wide. LÄS MER