Sökning: "genital immunity"
Visar resultat 1 - 5 av 22 avhandlingar innehållade orden genital immunity.
1. Development of novel immunization approaches to generate immunity in the female genital tract with special reference to genital herpes
Sammanfattning : Development of mucosal vaccines for inducing immunity in the female reproductive tract would have profound implications for the prevention of sexually transmitted diseases. Despite numerous efforts, no such vaccines are currently available for human use. LÄS MER
Sammanfattning : The overall aim of this thesis was to study the induction of B-cell immune responses in genital secretion and serum after mucosal vaccination in women. Oral inactivated B subunit whole-cell (B-WC) cholera vaccine and recombinant cholera toxin B subunit (CTB) alone were used as model immunogens. LÄS MER
Sammanfattning : Herpes simplex virus type 2 (HSV-2) is a sexually transmitted pathogen that infects the genital tract mucosa and is the most common case of genital ulcers in humans. Despite numerous studies, little is known about the mechanisms involved in immune protection and no anti-herpes vaccine has been developed to date. LÄS MER
Sammanfattning : Vaccination strategies for protection against sexually transmitted diseases (STDs) are lacking due to an incomplete understanding of genital tract T cell responses. This thesis dissects the generation of T helper subsets, including the recently discovered Th17 subset, during genital tract infection with a common sexually transmitted pathogen, Chlamydia trachomatis, and addresses vaccine requirements for the generation of genital tract CD4+ T cell immunity. LÄS MER
Sammanfattning : Sexually transmitted infections (STIs) cause a socioeconomic burden, morbidity and even mortality in a large part of the human population all over the world today. One of the most common genital ulcerative diseases is caused by herpes simplex virus type 2 with over 536 million people infected world-wide. LÄS MER