Sökning: "genetic susceptibility"
Visar resultat 11 - 15 av 498 avhandlingar innehållade orden genetic susceptibility.
11. Genetic susceptibility to psoriasis in Sweden
Sammanfattning : A common skin disease affecting about 2-3% of the population, psoriasis has an inheritance pattern that is unclear, but most probably many genes are involved in its pathogenesis. Other studies have suggested many susceptibility regions in the genome, but as yet independent studies have replicated only some of these regions located on chromosome 1q, 6p and 17q. LÄS MER
12. On certain genetic and metabolic risk factors for carotid stenosis and stroke
Sammanfattning : The present study evaluated genetic and metabolic factors influencing the risk of acute cerebrovascular disease (CVD) and internal carotid artery stenosis (ICA stenosis) in a Swedish community. The threonine (T) containing protein of the FABP2 A54T gene polymorphism has a greater affinity for long chain fatty acids (FFAs) than the alanine (A) containing protein. LÄS MER
13. Modeling genetic susceptibility to multiple sclerosis
Sammanfattning : The main aim of this thesis was to investigate genetic and environmental factors and their role in the etiology of Multiple Sclerosis (MS) by using comprehensive registry data or novel computationally intense methods. To date, over 100 genes associated with MS have been identified, but how they interact in the risk for the disease is not yet fully understood. LÄS MER
14. Genetic Studies of Rheumatoid Arthritis using Animal Models
Sammanfattning : Predisposition to autoimmune diseases such as, rheumatoid arthritis, diabetes, and multiple sclerosis, is caused by the effect of multiple genes and a strong influence from the environment. In this study, I have investigated genetic factors that confer susceptibility to rheumatoid arthritis in a rat model. LÄS MER
15. Genetic Mapping of Susceptibility Genes for Systemic Lupus Erythematosus
Sammanfattning : Systemic lupus erythematosus (SLE) is a complex autoimmune disease with unknown etiology. The aim of this thesis was to identify susceptibility regions through genetic mapping, using model-based linkage analysis on nuclear and extended SLE multicase families. LÄS MER