Sökning: "genetic heterogeneity"

Visar resultat 1 - 5 av 211 avhandlingar innehållade orden genetic heterogeneity.

1. 1. Breast cancer : Multifocality, heterogeneity, and related genetic signatures

   Författare :Gyula Pekar; Dumanski Jan; Sapino Anna; Uppsala universitet; []
   Nyckelord :breast; breast cancer multifocality; molecular phenotypes; intertumoral heterogeneity; biobanking; gene copy number aberrations;

   Sammanfattning : Breast carcinoma often exhibits a complex subgross morphology and may occupy a large volume of the breast tissue and show unifocal, multifocal or diffuse growth patterns. Expression of estrogen- and progesterone receptors, HER2 overexpression, tumor grade, and proliferative activity allows us to classify breast carcinoma into molecular subgroups (Luminal A, Luminal B, HER2-type, triple negative, and basal-like). LÄS MER

3. 2. The Role of Melanocyte Lineage Genes in Melanoma

   Författare :Adriana Sanna; Bröstcancer-genetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Melanoma; Genetic; Epigenetic; Heterogeneity; MITF; SOX10; CSD;

   Sammanfattning : Malignant melanoma accounts for the highest number of deaths among all skin cancer types, and its incidence has increased dramatically over the past decades. Despite the tremendous therapeutic advances, treatment resistant cells emerge in the vast heterogeneity of melanoma, driving tumor relapse and poor patient outcome. LÄS MER

4. 3. Genetic Heteroscedasticity for Domestic Animal Traits

   Författare :Majbritt Felleki; Erling Strandberg; Lars Rönnegård; Ole Fredslund Christensen; Högskolan Dalarna; Sveriges lantbruksuniversitet; []
   Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Quantitative genetics; genetic heteroscedasticity of residuals; genetic heterogeneity of environmental variation; genetic heterogeneity of residual variance; double hierarchical generalized linear models; teat count in pigs; litter size in pigs; milk yield in cows; somatic cell count in cows; Complex Systems – Microdata Analysis; Komplexa system - mikrodataanalys;

   Sammanfattning : Animal traits differ not only in mean, but also in variation around the mean. For instance, one sire’s daughter group may be very homogeneous, while another sire’s daughters are much more heterogeneous in performance. The difference in residual variance can partially be explained by genetic differences. LÄS MER

5. 4. Ethnic heterogeneity of the North-Swedish population : its origin and medical consequences

   Författare :Per-Olof Nylander; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Ethnic heterogeneity; Northern Sweden; Population genetics; Finns; Saamis; Genetic markers; Hypercholesterolemia;

   Sammanfattning : Northern Sweden shows a unique population structure with remarkable geographical variations in the distribution of genetic disorders as well as genetic markers like blood groups, serum groups and red cell enzyme types. The present-day population of northern Sweden is a mixture of people of Finnish, Saamish (Lappish) and Central-Swedish origin. LÄS MER

7. 5. Genetic Risk Factors for Systemic Lupus Erythematosus : From Candidate Genes to Functional Variants

   Författare :Anna-Karin Abelson; Marta Alarcón-Riquelme; Holger Luthman; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Systemic Lupus Erythematosus; SLE; association study; complex disease; genetic; Medical genetics; Medicinsk genetik;

   Sammanfattning : The aim of this thesis has been to identify genetic variants that increase the susceptibility for Systemic Lupus Erythematosus (SLE), an autoimmune disease caused by a complex interplay between various genetic and environmental factors. Five different candidate genes were selected through different strategies, and were analysed for association with SLE in an attempt to distinguish some of the underlying mechanisms of this disease. LÄS MER