Sökning: "genetic correlation"

Visar resultat 1 - 5 av 368 avhandlingar innehållade orden genetic correlation.

1. 1. On the aetiology of ALS : a comprehensive genetic study

   Författare :Caroline Ingre; Peter M Andersen; Rayomand Press; Siddharthan Chandran; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ALS; risk factor; VAPB; SOD1; amyotrophic lateral sclerosis; ATXN2; SMN1; SMN2; PFN1; 50 bp deletion in SOD1 promotor; population-specific genetic variations; Neurology; neurologi;

   Sammanfattning : Introduction: Amyotrophic lateral sclerosis (ALS) is a deadly, progressive neuromuscular disease that affects individuals all over the world. About 10% of the patients have a familial predisposition (FALS) while the remainder of cases are isolated or sporadic (SALS) and of unknown cause. LÄS MER

3. 2. Genetic studies of diabetes in northern Sweden

   Författare :Sofia Mayans; Dan Holmberg; Mats Eliasson; Outi Vaarala; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Diabetes; families; genetic; association; SNP; linkage; TCF7L2; CTLA-4; Calpain-10; Medical genetics; Medicinsk genetik;

   Sammanfattning : Diabetes mellitus represents a group of metabolic disorders caused by both environmental and genetic factors. The two most common forms of diabetes are type 2 diabetes (T2D) and type 1 diabetes (T1D). T2D is associated with obesity and the disease is caused by insulin resistance and pancreatic b-cell dysfunction. LÄS MER

4. 3. Genetic Heteroscedasticity for Domestic Animal Traits

   Författare :Majbritt Felleki; Erling Strandberg; Lars Rönnegård; Ole Fredslund Christensen; Högskolan Dalarna; Sveriges lantbruksuniversitet; []
   Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Quantitative genetics; genetic heteroscedasticity of residuals; genetic heterogeneity of environmental variation; genetic heterogeneity of residual variance; double hierarchical generalized linear models; teat count in pigs; litter size in pigs; milk yield in cows; somatic cell count in cows; Complex Systems – Microdata Analysis; Komplexa system - mikrodataanalys;

   Sammanfattning : Animal traits differ not only in mean, but also in variation around the mean. For instance, one sire’s daughter group may be very homogeneous, while another sire’s daughters are much more heterogeneous in performance. The difference in residual variance can partially be explained by genetic differences. LÄS MER

5. 4. Genetic Variation and Relatedness of Freshwater Pearl Mussel Margaritifera margaritifera L. populations

   Författare :Amra Hadzihalilovic-Numanovic; Larry Greenberg; Nils Ryman; Karlstads universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Margaritifera margaritifera; genetic variation; age structure; genetic distance; Biology; Biologi; Biology; Biologi;

   Sammanfattning : The two papers presented in this thesis focus on population genetic study on freshwater pearl mussel populations in Sweden, using RAPD method. In paper I, I examine genetic variation within and between 5 populations in a single drainage area in south western Sweden. LÄS MER

7. 5. Population differentiation in Lythrum salicaria along a latitudinal gradient

   Författare :Katarina Olsson; Jon Ågren; Susan Kalisz; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ecology; additive genetic variance; clinal variation; evolutionary constraints; G matrix; genetic correlation; natural selection; pollen limitation; population differentiation; Ekologi; Terrestrial; freshwater and marine ecology; Terrestisk; limnisk och marin ekologi; ekologisk botanik; Ecological Botany;

   Sammanfattning : In this thesis, quantitative genetic approaches, common-garden experiments, and field studies were combined to examine patterns of population differentiation and the genetic architecture of characters of putative adaptive significance in the widely distributed perennial herb Lythrum salicaria. In this work, I (1) documented patterns of population differentiation in phenology, life-history, and morphology along latitudinal gradients at different geographical scales, (2) investigated the genetic architecture of phenology, flower morphology, and inflorescence size, and (3) combined estimates of phenotypic selection in the field with information on the genetic variance-covariance matrix (G) to examine potential constraints to adaptive evolution. LÄS MER