Sökning: "generalized osteoarthritis"

Hittade 4 avhandlingar innehållade orden generalized osteoarthritis.

  1. 1. Wrist osteoarthritis : causes, treatment and outcome

    Författare :Elin Swärd; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Wrist osteoarthritis is rare compared to osteoarthritis in the finger joints or thumb base and affects younger patients. Its etiology is heterogenous, and osteoarthritis may be caused by traumatic injuries, as well as by nontraumatic medical conditions. LÄS MER

  3. 2. Algorithmic discovery, development and personalized selection of higher-order drug cocktails : A label-free live-cell imaging & secretomics approach

    Författare :Efthymia Chantzi; Mats G Gustafsson; Ulf Hammerling; Andreas Bender; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug combination discovery and development; personalized pharmacotherapy; higher-order drug combination analysis; quantitative label-free live-cell imaging; secretomics; cell-cell communication; deep learning; convolutional neural networks; data mining; MapReduce; resampling; generalized highest single agent; COMBImageDL; COMBSecretomics; Bioinformatics; Bioinformatik; Pharmacology; Farmakologi; Engineering Science; Teknisk fysik;

    Sammanfattning : An upward trend in clinical pharmacology is the use of multiple drugs to combat complex and co-occurring diseases due to better efficacy, decreased toxicity and reduced risk of evolving resistance. Despite high late-stage attrition rates and the need for multi drug treatments, most drug discovery and development efforts are still mainly focused on new one-size-fits-all monotherapies. LÄS MER

  4. 3. Inflammatory and degenerative disease in the temporomandibular joint

    Författare :Göran W Gynther; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :clinical findings; degenerative changes; generalized osteoarthritis; histology; immunohistochemistry; internal derangement; radiographic changes; rheumatoid arthritis; synovial inflammation; temporomandibular jointISBN 91-628-1 9;

    Sammanfattning : Temporomandibular joint (TMJ) arthroscopy is an established technique with high diagnostic accuracy regarding synovitis and degenerative changes of the articular fibrocartilage and disk. However, so far no studies have been done to correlate the macroscopic and histologic findings with each arthroscopic criterion. LÄS MER

  5. 4. A clinical study of uncemented hip arthroplasty : radiological findings of host-bone reaction to the stem

    Författare :Henrik Bodén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Arthroplasty; bone remodelling; DEXA; fixation; geometrical design; hydroxyapatite; osteoarthritis; scintigraphy; stem size; stress-shielding; tapered; titanium; uncemented; weight-bearing.;

    Sammanfattning : In total hip arthroplasty (THA), the main reason for failure leading to revision is aseptic loosening. Both mechanical and biological effects act in the loosening process, the factors may be implant design, fixation mode or technique, as well as biological factors unique to the individual. LÄS MER