Sökning: "general pulmonary distribution model"
Hittade 2 avhandlingar innehållade orden general pulmonary distribution model.
1. Novel Pharmacometric Methods for Informed Tuberculosis Drug Development
Sammanfattning : With approximately nine million new cases and the attributable cause of death of an estimated two millions people every year there is an urgent need for new and effective drugs and treatment regimens targeting tuberculosis. The tuberculosis drug development pathway is however not ideal, containing non-predictive model systems and unanswered questions that may increase the risk of failure during late-phase drug development. LÄS MER
2. Ventilation/Perfusion Matching and its Effect on Volatile Pharmacokinetics
Sammanfattning : The mismatching of alveolar ventilation and perfusion (VA/Q) is the major determinant of impaired gas exchange. The gold standard for analyzing VA/Q distribution is the multiple inert gas elimination technique (MIGET), conventionally based on gas chromatography (GC), and, although simple in principle, a technically demanding procedure limiting its use. LÄS MER