Sökning: "gene-gene interactions"

Visar resultat 6 - 10 av 18 avhandlingar innehållade orden gene-gene interactions.

  1. 6. Rule-based Models of Transcriptional Regulation and Complex Diseases : Applications and Development

    Författare :Susanne Bornelöv; Jan Komorowski; Claes Wadelius; Joanna Polanska; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Histone modification; Transcription factor; Transcriptional regulation; Next-generation sequencing; Feature selection; Machine learning; Rule-based classification; Asthma; Allergy; Bioinformatik; Bioinformatics;

    Sammanfattning : As we gain increased understanding of genetic disorders and gene regulation more focus has turned towards complex interactions. Combinations of genes or gene and environmental factors have been suggested to explain the missing heritability behind complex diseases. LÄS MER

  3. 7. Genes, lifestyle and coronary heart disease risk-epidemiological interaction studies

    Författare :Jaana Gustavsson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Coronary heart disease; gene-lifestyle interaction; APOE; FTO; GHRL; smoking; physical activity; diet; obesity;

    Sammanfattning : Coronary heart disease (CHD) has multifactorial background involving both genetic and lifestyle factors, but much is still unknown about their interactions. The aim of this thesis was to study interactions focusing on apolipoprotein E (APOE), fat mass and obesity-related (FTO) and ghrelin/obestatin prepropeptide (GHRL) genes, as well as smoking, physical activity and diet. LÄS MER

  4. 8. Bioinformatic approaches to gene expression in leukemia. Networks and deconvolution

    Författare :Linnea Järvstråt; Hematogenomics; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; bioinformatics; acute myeloid leukemia; networks; deconvolution; microarrays; ChIP-seq; DEK; WT1;

    Sammanfattning : The aim of this thesis is develop methods to extract information from high-dimensionality data and to apply them in looking at gene-gene and gene-protein interactions in Acute Myeloid Leukemia (AML). The in silico methods developed can be used with data from other systems. LÄS MER

  5. 9. Gene regulation and immune mechanisms in multiple sclerosis experimental models

    Författare :Monica Sofia Calado Marta; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Our strategy was to fine map and identify, in an unbiased way, genes or small regions that regulate myelin-oligodendrocyte glycoprotein-induced EAE (MOG-EAE). Such genes are important as they can then be tested for a role in MS. LÄS MER

  7. 10. Integrative Analysis of Dynamic Networks

    Författare :Vinay Jethava; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Lovasz theta function; dynamic networks; integrative analysis; probabilistic graphical models; support vector machines; graph kernels;

    Sammanfattning : Networks play a central role in several disciplines such as computational biology, social network analysis, transportationplanning and many others; and consequently, several methods have been developed for network analysis. However, in many cases, the study of a single network is insufficient to discover patterns with multiple facets and subtlesignals. LÄS MER