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  1. 1. Contributions to Statistical Analysis of Gene Expression Data

    Författare :Anders Sjögren; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; DNA microarray; differential expression; gene regulation; variance stabilising transformation; permutation; reference gene; housekeeping gene; bootstrap; quality control QC ; quality assurance QA ; quality assessment; empirical Bayes; weighted moderated t-statistic; WAME; DNA microarray;

    Sammanfattning : .... LÄS MER

  3. 2. Statistical analysis of gene expression data

    Författare :Erik Kristiansson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; gene expression; DNA microarrays; linear models; empirical Bayes; quality control; gene regulation; categorical data analysis; logistic regression; heavy metal stress; ecotoxicology; gene expression;

    Sammanfattning : Microarray technology has become one of the most important tools for genome-wide mRNA measurements. The technique has been successfully applied to many areas in modern biology including cancer research, identification of drug targets, and categorization of genes involved in the cell cycle. LÄS MER

  4. 3. Tripeptidyl-Peptidase II : Structure, Function and Gene Regulation

    Författare :Ann-Christin Lindås; Birgitta Tomkinson; Mikael Widersten; Ralf Morgenstern; Uppsala universitet; []
    Nyckelord :Biochemistry; gene regulation; protein expression; enzyme kinetics; tripeptidyl-peptidase II; proteasome; intracellular protein degradation; exopeptidase; Biokemi;

    Sammanfattning : The protein degradation process is of vital importance for the cell to maintain cellular functions. An important enzyme in this process is the multimeric tripeptidyl-peptidase II (TPP II). It removes tripeptides from a free N-terminus of the substrates. LÄS MER

  5. 4. Organization and regulation of mitochondrial gene expression

    Författare :Roger Salvatori; Martin Ott; Benoit Kornmann; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Mitochondria; mitochondrial gene expression; post-transcriptional regulation; mitochondrial ribosome; protein-protein proximity; BioID; feedback loop; Biochemistry; biokemi;

    Sammanfattning : Mitochondria possess their own genome, remnant of the ancestral eubacterial endosymbiont DNA. This mitochondrial genome encodes mostly few key subunits of the respiratory chain. In order to synthesize these few proteins, mitochondria contain a complete gene expression machinery. LÄS MER

  7. 5. Regulation of gene expression in fruit flies : how does it start, and will it be remembered?

    Författare :Aman Zare; Per Stenberg; Yuri B. Schwartz; Åsa Rasmuson-Lestander; Guillaume Filion; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Drosophila; epigenetics; transcription; gene regulation; transcription maintenance; CBP; polymerase pausing; Polycomb group proteins; transgenerational inheritance of transcriptional response; gut microbiome; molekylärbiologi; Molecular Biology;

    Sammanfattning : One of the most distinctive features of eukaryotic chromosomes is the bundling of DNA together with functionally associated RNA and proteins in chromatin. This allows huge amounts of DNA to be packed inside the very tiny space of the nucleus, and alterations in the structure of chromatin enable access to the DNA for transcription (“reading” genes by production of RNA copies). LÄS MER