Sökning: "gene duplications"

Visar resultat 21 - 25 av 81 avhandlingar innehållade orden gene duplications.

  1. 21. Antibody repertoires : Exploration of their role in allergic disease and facilitation of reliable analyses thereof

    Författare :Linnea Thörnqvist; Institutionen för immunteknologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; allergen; allergic disease; antibody bioinformatics; antibody repertoire; B cells; epitope; immunogloblulin; immunogloblulin germline gene; IgE; specific immunotherapy; stereotyped antibody;

    Sammanfattning : Allergic disease affects millions of individuals worldwide and leads to both impaired life quality of the affected individuals and large economic costs for the society. Allergen-specific antibodies of IgE type act as one of the key players in the disease, by activating effector cells upon binding of its allergen. LÄS MER

  3. 22. Environmental Contaminants, Recombination and Cancer : Investigations on the molecular mechanisms of spontaneous and induced recombination in the hprt gene of Chinese hamster cells

    Författare :Thomas Helleday; Mark Meuth; Stockholms universitet; []
    Nyckelord :toxikologisk genetik; Genetic Toxicology;

    Sammanfattning : Recombination results in rearrangement of the genetic material contained in the chromosomes inherited from the mother and father and this process is also involved in repairing damage to the genome. Occasionally, the machinery that performs recombination malfunctions and this may lead to illegitimate recombination events which inactivate tumor suppressor genes or activate protooncogenes. LÄS MER

  4. 23. Characterization of a putative tumor suppressor region identified by the elimination test on human 3p21.3

    Författare :Hajnalka Kiss; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Elimination test; common eliminated region 1 CER1 ; 3p21.3; tumor suppressor gene; large scale sequencing; LIMD1; LZTFL1; FYC01; TMEM7; LRRC2; LUZP3.;

    Sammanfattning : An experimental system, called the elimination test (Et), was developed to identify tumor growth antagonizing genes. Chromosome 3 containing microcell hybrids (MCHs) were passaged through SCID mice and regular deletion of the short arm of chromosome 3 (3p) were found by cytogenetic and molecular methods. LÄS MER

  5. 24. Probabilistic Reconciliation Analysis for Genes and Pseudogenes

    Författare :Owais Mahmudi; Jens Lagergren; Cedric Chauve; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Phylogenetics; Evolution; Reconciliation Analysis; Bayesian Inference; Datalogi; Computer Science;

    Sammanfattning : Phylogeneticists have studied the evolution of life from single celled organisms to the astonishing biodiversity around us for a long time now. The relationship between species is often expressed as a binary tree - the tree of life. LÄS MER

  7. 25. Evolutionary aspects of the immunoglobulin heavy chain constant locus

    Författare :Hodjatallah Rabbani; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The human Ig heavy chain constant locus (IGHC) is composed of nine functional and two pseudo genes. Extensive polymorphism consisting of deletions, duplications and point mutations have been observed in this locus. LÄS MER