Sökning: "gastrointestinal precipitation"

Visar resultat 1 - 5 av 6 avhandlingar innehållade orden gastrointestinal precipitation.

  1. 1. Investigation and Prediction of Small Intestinal Precipitation of Poorly Soluble Drugs : a Study Involving in silico, in vitro and in vivo Assessment

    Författare :Sara Carlert; Hans Lennernäs; Bertil Abrahamsson; Patrick Augustijns; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gastrointestinal precipitation; crystallization; crystal nucleation; crystal growth; classical nucleation theory; poorly soluble drugs; drug absorption; biopharmaceutics classification system; in vitro in vivo correlations IVIVC ; in silico prediction; human intestinal fluid; dog intestinal fluid; simulated intestinal fluid; Biofarmaci; Biopharmaceutics;

    Sammanfattning : The main objectives of the present project were to increase the understanding of small intestinal precipitation of poorly soluble pharmaceutical drugs, investigate occurrence of crystalline small intestinal precipitation and effects of precipitation on absorption. The aim was to create and evaluate methods of predicting crystalline small intestinal drug precipitation using in vivo, in vitro and in silico models. LÄS MER

  3. 2. Precipitation, Raw Water Quality, Drinking Water Treatment and Gastrointestinal Illness

    Författare :Andreas Tornevi; Bertil Forsberg; Gordon Langston Nichols; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epidemiologi; Epidemiology;

    Sammanfattning : Background On numerous occasions, outbreaks of acute gastrointestinal illnesses (AGI) have been linked to municipal drinking water in the industrialised world. Many of the reported outbreaks were observed after heavy rainfall events, which suggests that such events could result in a deterioration in the quality of drinking water. LÄS MER

  4. 3. Fractionation of lipids and protein from the microalga Nannochloropsis oculata

    Författare :Lillie Cavonius; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; food processing; lipids; pH-shift process; n 3 polyunsaturated fatty acids; solubilization; acid; proteins; Nannochloropsis oculata; alkaline; microalgae; precipitation; in vitro digestion;

    Sammanfattning : To feed Earth’s growing population, microalgae have been proposed as a source of protein and long-chain n-3 polyunsaturated fatty acids (LC n-3 PUFAs). Currently, microalgae are mainly sold either as whole biomass, or the economically valuable LC n-3 PUFA fraction is extracted with organic solvents. LÄS MER

  5. 4. Improved Molecular Understanding of Lipid-Based Formulations : for Enabling Oral Delivery of Poorly Water-Soluble Drugs

    Författare :Linda C. Alskär; Christel Bergström; Brendan Griffin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; lipid-based formulation; poorly water-soluble drug; solubility prediction; molecular properties; lipid digestion; precipitation; solid state; intestinal solubilization; in vitro in vivo correlation IVIVC ; coadministration; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : The majority of emerging drug candidates are not suited for conventional oral dosage forms, as they do not dissolve in the aqueous environment of the gastrointestinal (GI) tract. Consequently, a large number of enabling formulation strategies have emerged. LÄS MER

  7. 5. Seaweed as a sustainable source of food protein: maximizing seaweed protein content, protein recovery, and nutritional quality

    Författare :João Pedro Trigo; Chalmers tekniska högskola; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; protein isolation; intestinal permeability; detergent; thermal water treatment; protein shift; wastewater; elemental compositional; macroalgae; gastrointestinal digestion; cultivation;

    Sammanfattning : This thesis focuses on utilizing seaweed, such as Saccharina latissima and Ulva fenestrata , as sustainable food protein sources to complement terrestrial protein currently limited by land and water supply. While seaweed holds promise, its protein content is lower than pulses and antinutrients reduce protein nutritional quality. LÄS MER