Sökning: "gastrointestinal cell lines"
Visar resultat 1 - 5 av 13 avhandlingar innehållade orden gastrointestinal cell lines.
1. Mucus and mucins during gastrointestinal infections
Sammanfattning : The gastrointestinal tract is protected by a continuously secreted mucus layer formed by mucin glycoproteins. The mucus layer and mucins change dynamically during infection. The main focus of this thesis was to investigate the changes in mucin and the mucus layer in the gastrointestinal tract during infection with the gastrointestinal pathogens C. LÄS MER
2. Functions of PDGF-A and -C. Essential ligands for the PDGF alpha receptor
Sammanfattning : Altered protein kinase activity is a contributing factor in many diseases including most formsof human malignancies, and there is reason to believe that protein kinases will prove to be majordrug targets in the treatment of cancer. Protein kinases mediate most of the signal transduction ineukaryotic cells, regulating cellular events such as transcription, metabolism, proliferation,cytoskeletal rearrangement, migration, differentiation and apoptosis. LÄS MER
3. Gene Expression in mESC Deficient in FGFR Signalling and the Identification of the Novel Gene Ened
Sammanfattning : Embryonic stem cells (ESCs) are derived from the inner cell mass (ICM) of blastocyst stage embryos, and upon differentiation into embryoid bodies (EBs) they recapitulate the genetic, cellular and morphological events occurring in early embryogenesis. Among several signalling pathways and inductive factors, the fibroblast growth factors (FGFs) and their receptors (FGFRs) have been shown to be important during early embryogenesis. LÄS MER
4. Role of oxidative stress response in radiosensitivity
Sammanfattning : The quality of the ionizing radiation (IR) can be described in terms of its nature, photons or particles, and their corresponding energies. The energy is classified in terms of High or Low linear energy transfer that will produce a different distribution of DNA damage and other molecules in the cell either by direct action or indirect action. LÄS MER
5. MicroRNA and energy metabolism in gastrointestinal tumors
Sammanfattning : MicroRNAs (miRNAs) contribute to cancer development and drug resistance via cellular biological processes, including metabolic pathways. Energy metabolism plays a significant role to maintain tumor proliferation in gastrointestinal (GI) cancers. However, the roles of miRNAs and energy metabolism in GI cancers are not fully understood. LÄS MER