Sökning: "gallstone disease"

Visar resultat 16 - 20 av 43 avhandlingar innehållade orden gallstone disease.

1. 16. Studies on cholesterol and bile acid metabolism in Chinese cholesterol gallstone patients

   Författare :Zhao-Yan Jiang; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cholesterol gallstone disease; ABCG5 ABCG5; SRBI; ACAT2; Gender; Bile acids; Liver; Intestine;

   Sammanfattning : Liver and intestine are important organs for the metabolism of cholesterol and bile acids in the body. Dysfunction in cholesterol and bile acid metabolism may lead to diseases such as cholesterol gallstone (GS) disease and atherosclerosis. LÄS MER

3. 17. Modulation of bile acid and cholesterol metabolism in health and disease

   Författare :Cecilia Gälman; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Bile acids - cholesterol - gallstone - cholic acid - cholestyramine - high performance liquid chromatography - species - C4 - 7alpha-hydroxy-4-cholesten-3 -one cholesterol 7alpha-hydroxylase - lipoproteins - hyperlipidemia - statins - resins - diurnal variation - ASBT - 3-hydroxy-3-methylglutaryl coenzyme A;

   Sammanfattning : An increased level of plasma cholesterol is associated with premature development of atherosclerosis. It is therefore important to understand the regulation of plasma cholesterol. Stimulation of hepatic bile acid synthesis is a strategy to reduce plasma cholesterol. This partly occurs due to an induction of hepatic LDL receptors. LÄS MER

4. 18. On the regulation of hepatic cholesterol and bile acid metabolism in gallstone patients

   Författare :Carl-Gustaf Hillebrant; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Bile acid synthesis; biliary lipids; cholesterol synthesis; cholesterol 7a-hydroxylase; cholesterol synthesis inhibitor; chenodeoxycholic acid; cholestyramine; 7a-hydroxy-4-cholesten-3-one; HMG CoA reductase; lathosterol; lipoproteins; lithocholic acid; plasma apheresis; ursodeoxycholic acid;

   Sammanfattning : The liver plays an important role in the regulation of cholesterol homeostasis, therefore also in the pathogenesis of arteriosclerosis and gallstone disease. The quantitatively most important way by which cholesterol is removed from the human body is via the bile, either as free cholesterol or after transformation to bile acids. LÄS MER

5. 19. Understanding the molecular mechanisms of bile acid receptor activation for the treatment of human liver disease

   Författare :Samer Al-Dury; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicinska sjukdomar; Gastroenterologi och hepatologi; FXR; IBAT; Gallsyror; Obesitas; Gallstenar;

   Sammanfattning : Farnesoid X receptor (FXR) is a nuclear transcription factor that is activated by bile acids and regulates bile acid homeostasis, glucose and lipid metabolism. FXR activation by a ligand has been identified as a therapeutic modality for a range of liver and metabolic diseases. LÄS MER

7. 20. Laparoscopic cholecystectomy : patients experiences of self-reported symptoms, perception of health and sense of coherence in a short and long term perspective

   Författare :Cajsa Barthelsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Ambulatory surgery; anxiety; controlled trial; day surgery; gallstone disease; health; laparoscopic cholecystectomy; pain; sense of coherence; symptom distress; symptom occurrence;

   Sammanfattning : The aim of Study I was to explore patients' experiences related to gallstone disease and to their experiences of postoperative symptoms during the first week following outpatient laparoscopic cholecystectomy (LC). Twelve patients treated in day surgery were interviewed one week after surgery and a qualitative analysis was performed. LÄS MER