Sökning: "galectin ligand"
Visar resultat 1 - 5 av 19 avhandlingar innehållade orden galectin ligand.
1. Galectin binding proteins in serum and bronchoalveolar lavage -in healthy and pathological conditions
Sammanfattning : Galectins are carbohydrate binding proteins, implicated in conditions of both inflammation and cancer. Connections between chronic inflammation and cancer are proposed by the increased remodelling and proliferation that occurs, leading to enhanced survival and proliferation of malignant cells. LÄS MER
2. Design, Synthesis and Thermodynamic Studies of Galectin Ligands
Sammanfattning : The signaling within and between cells in biology is governed by molecular recognition between natural or synthetic ligands and proteins. This thesis project aimed to investigate the thermodynamic properties of specific interaction between synthetic ligands and galectin proteins. LÄS MER
3. Galectin-3 Ligand Binding: Mechanism and Driving Forces
Sammanfattning : .... LÄS MER
4. Molecular basis for galectin-ligand interactions : Design, synthesis and analysis of ligands
Sammanfattning : Galectins are a class of β-galactoside-binding proteins that bind glycoconjugates and have been implicated in cancer, regulation of immunity and inflammation. Design and synthesis have achieved highly potent and selective galectin ligands that can inhibit interactions with glycoproteins and have consequent cellular effects. LÄS MER
5. Functional properties of galectin-3. Beyond the sugar binding
Sammanfattning : Contemporary diseases like diabetes, asthma, atherosclerosis etc. are marked by chronic inflammation, often supported by the activity of different macrophages. Proteins from galectin family were found to contribute to disease pathophysiology. Therefore, there is an intensive interest in understanding different galectin functions. LÄS MER