Sökning: "g2 m"

Visar resultat 1 - 5 av 61 avhandlingar innehållade orden g2 m.

  1. 1. Mapping the Golgi retention signal in the G1 membrane glycoprotein of Uukuniemi virus, a member of the Bunyaviridae family

    Författare :Agneta M. Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Golgi complex; retention signal; protein transport; virus membrane glycoproteins; virus budding; Uukuniemi virus; Phlebovirus; Bunyaviridae;

    Sammanfattning : Newly synthesized secretory and integral membrane proteins destined for the plasma membrane are transported along the exocytic pathway from the endoplasmic reticulum (ER) via the Golgi complex (GC) to the cell surface. Some of the transported proteins contain information, which target them to their correct intracellular locations. LÄS MER

  2. 2. Regulation of productivity in Trichoplusia ni and Spodoptera frugiperda Sf9 serum-free cultures

    Författare :Karin Calles; Lena Häggström; Gunnel Dalhammar; KTH; []
    Nyckelord :ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; Biotechnology; Insect cells; BEVS; Spodoptera frugiperda; Sf9; Trichoplusia ni; BTI-Tn-5B1-4; specific productivity; conditioned medium; conditioned medium factors; cell cycle; synchronization; G2 M; Bioteknik; Bioengineering; Bioteknik;

    Sammanfattning : The aim of this work has been to characterize the effects of conditioned medium (CM) on insect cell productivity and physiology in order to get a better understanding about the mechanisms that regulate productivity in serum-free media. Two cell lines have been investigated, Spodoptera frugiperda (Sf9) and Trichoplusia ni (T. ni, BTI-Tn-5B1-4). LÄS MER

  3. 3. Tracing the interplay between cellular metabolism and cell cycle

    Författare :Irena Roci; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : Cancer cells are more vulnerable to targeting during S-G2-M cell cycle phases due to common deregulations in cell cycle checkpoint mechanisms. Most common cancer drugs target processes in the S-G2-M phases, often causing negative effects on proliferating normal cells. LÄS MER

  4. 4. Interactive antiproliferative mechanisms when 5-fluorouracil is combined with cisplatin or ionizing radiation : an in vivo and in vitro experimental study

    Författare :Urban D. Nylén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : Results from clinical studies and experimental investigations have given evidence of a synergistic effect when 5- fluorouracil (5-FU) has been combined with radiation or cisplatin (CDDP). From earlier experiments performed by the research team we know, that addition of S-FU to CDDP can synergistically increase the antiproliferative effect. LÄS MER

  5. 5. Cell cycle regulation and DNA damage response : a record of polo-like kinase 1 activity

    Författare :Elvira Hukasova; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Sammanfattning : Division and cell proliferation is an essence of life. A human cell has in its core a very simple yet a very complex machinery to coordinate cell cycle activities and events. LÄS MER