Sökning: "fusion proteins"

Visar resultat 11 - 15 av 271 avhandlingar innehållade orden fusion proteins.

  1. 11. Borrelia channel-forming proteins : structure and function

    Författare :Ignas Bunikis; Sven Bergström; Steven Norris; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Borrelia; Lume disease; relapsing fever; BesC; drug efflux; DipA; P66; porins; Molecular biology; Molekylärbiologi; molekylärbiologi; Molecular Biology;

    Sammanfattning : Borrelia is a Gram-negative, corkscrew-shaped bacterium transmitted by infected ticks or lice. Borreliae are subdivided into pathogens of two diseases: Lyme disease, caused mainly by B. burgdorferi, B. afzelii and B. LÄS MER

  3. 12. Targeting HER2-expressing tumors with potent drug conjugates and fusion toxins based on scaffold proteins

    Författare :Haozhong Ding; Torbjörn Gräslund; Stefan Ståhl; Harald Kolmar; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Targeted therapy; affibody molecules; ADAPT molecules; AffiDC; fusion toxins; HER2; Biotechnology; Bioteknologi;

    Sammanfattning : Targeted therapy is an emerging treatment for a variety of cancers. Small- sized scaffold proteins are an alternative to conventional antibody-based targeting molecules. LÄS MER

  4. 13. Functional characterization of the secretory pathway and the role of COPI vesicles

    Författare :Johan Hiding; Göteborgs universitet; []
    Nyckelord :Golgi; Phosphoinositides; Fusion; COPI; ARF1; Proteomics; ER;

    Sammanfattning : In the secretory pathway, proteins synthesized in the endoplasmatic reticulum move through the Golgi apparatus in a cis-to-trans direction and then sorts into different types of vesicles at the trans-Golgi network. How intracellular transport takes place has been the focus of cell biology research for a long time. LÄS MER

  5. 14. Protein production and purification in structural genomics

    Författare :Martin Hammarström; Per-Åke Nygren; Torleif Härd; Helena Berglund; Herman van Tilbeurgh; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Recombinational cloning; Escherichia coli; gene expression; fusion proteins; solubility; circular dichroism; nuclear magnetic resonance; Structural biochemistry; Strukturbiokemi;

    Sammanfattning : The number of gene products available for structural and functional study is increasing at an unprecedented rate as a result of the successful whole genome sequencing projects. Systematic structure determination of proteins on a genomic scale, called structural genomics, can significantly contribute to the field of protein science and to functional annotation of newly identified genes. LÄS MER

  7. 15. Selective extraction systems for detection and purification of membrane proteins

    Författare :Ulf Sivars; Biokemi och Strukturbiologi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; partitioning; Aqueous two-phase systems; separation; membrane proteins; detergent; micelle; polymer; Biochemistry; affinity; Metabolism; Biokemi;

    Sammanfattning : Increased understanding of membrane proteins is important for characterization of biochemical processes. Improved membrane protein isolation methods is a key issue for effective functional and structural determination of the large amount of unknown membrane proteins. LÄS MER