Sökning: "fusion gene"

Visar resultat 6 - 10 av 222 avhandlingar innehållade orden fusion gene.

  1. 6. Gene fusion in protein engineering : design of novel peptides and bifunctional enzymes

    Författare :Sarah Fredriksson; Tillämpad biokemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cadmium; Bifunctional enzyme; Catalytic triad; Channeling; Coenzyme recycling; Galactose dehydrogenase; ß-Galactosidase; Gene fusion; Hexapeptide; Lactate dehydrogenase; Linker region; Multifunctional enzymes; Oligomeric protein; NADH; Phage; OmpA; Biochemistry; Biokemi; metabolism; Biotechnology; Bioteknik;

    Sammanfattning : The gene fusion technique is widely used in protein engineering and in this thesis it constitutes the basis of both the construction of artificial bifunctional enzymes and the display of two novel peptides. Artificial bifunctional enzymes have been used as model systems in the studies of native multifunctional enzymes and proximity effects within these complexes. LÄS MER

  3. 7. Genomic characterization of non-small cell lung cancer - clinical and molecular implications

    Författare :Anna F Karlsson; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Lung cancer; histology; non-small cell lung cancer; gene expression; gene fusion; Methylation;

    Sammanfattning : Lung cancer accounts for 1.6 million cancers annually and 1.3 million deaths per year make the disease the deadliest type of cancer. Smoking is the most prominent cause. LÄS MER

  4. 8. Studies of Fusion Oncogenes and Genomic Imbalances in Human Tumors

    Författare :Fredrik Persson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer genetics; fusion oncogene; gene amplification; array CGH; PLAG1; HMGA2; FGFR1; MDM2; pleomorphic adenoma; carcinoma ex pleomorphic adenoma; liposarcoma;

    Sammanfattning : Cancer is a genetic disease caused by mutations and chromosome rearrangements affecting oncogenes and tumor suppressor genes in particular. Molecular analyses of recurrent translocations in hematological disorders, as well as in certain solid tumor types, have shown that they frequently result in fusion oncogenes. LÄS MER

  5. 9. Studies of PLAG1 and HMGIC fusion oncogenes in human tumors

    Författare :Anna-Karin Ström; Göteborgs universitet; []
    Nyckelord :Pleomorphic adenoma; carcinoma ex pleomorphic adenoma; lipoblastoma; PLAG1; HMGIC; chromosome translocation; promoter swapping; fusion oncogene; gene amplification;

    Sammanfattning : .... LÄS MER

  7. 10. On the role of the fusion protein DEK-NUP214 in leukemogenesis

    Författare :Malin Ageberg; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mRNA translation; Medicin människa och djur ; fusion gene; Medicine human and vertebrates ; leukemia;

    Sammanfattning : The t(6;9) translocation is found in a subset of patients with acute myeloid leukemia (AML) and is associated with a poor prognosis. The translocation results in the formation of the DEK-NUP214 fusion protein containing almost the entire nuclear protein DEK and two thirds of the nucleoporin NUP214. LÄS MER