Sökning: "fusion gene transcripts"
Visar resultat 1 - 5 av 16 avhandlingar innehållade orden fusion gene transcripts.
1. Detection of fusion genes and fusion proteins in sarcoma : methodological and clinical aspects
Sammanfattning : Ewing's sarcoma/PNET and synovial sarcoma, all regarded as high-grade tumours, have their peak incidence during the second decade of life, thus affecting children and adolescents. Both tumour types have specific chromosomal translocations, i.e. t(11;22) and t(X;18), respectively, resulting in fusion genes coding for chimeric proteins. LÄS MER
2. Expression and Mutation Analyses of Candidate Cancer Genes In Situ
Sammanfattning : Cancers display heterogeneity in genetic profiles of the individual cancer cells and in the composition of different malignant and non-malignant cell populations. Such intra-tumor heterogeneity plays a role in treatment response and the emergence of resistance to cancer therapies. LÄS MER
3. Spatially Resolved Gene Expression Analysis
Sammanfattning : Spatially resolved transcriptomics has greatly expanded our knowledge of complex multicellular biological systems. To date, several technologies have been developed that combine gene expression data with information about its spatial tissue context. LÄS MER
4. Studies of gene fusions and copy number alterations in salivary and adnexal neoplasms
Sammanfattning : Cancer is a genetic disease caused by the accumulation of genetic changes such as mutations and chromosomal rearrangements. An increasing number of genetic studies of both hematological and solid neoplasms have shown that recurrent chromosome translocations often result in fusion oncogenes. LÄS MER
5. Minimal Residual Disease Assessment in Childhood Acute Lymphoblastic Leukemia
Sammanfattning : Traditionally, response to treatment in hematological malignancies is evaluated by light microscopy of bone marrow (BM) smears, but due to more effective therapies more sensitive methods are needed. Today, detection of minimal residual disease (MRD) using immunological and molecular techniques can be 100 times more sensitive than morphology. LÄS MER