Sökning: "functional specialization"

Visar resultat 16 - 20 av 153 avhandlingar innehållade orden functional specialization.

1. 16. Ground and Excited State Aromaticity : Design Tools for π-Conjugated Functional Molecules and Materials

   Författare :Christian Dahlstrand; Henrik Ottosson; Miguel Solà; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; fulvene; fulvalene; polyfulvene; aromaticity; triplet state; excited state; Clar structure; polybenzenoid hydrocarbons PBH ; conjugated polymers; computational chemistry; optical spectroscopy; Kemi med inriktning mot organisk kemi; Chemistry with specialization in Organic Chemistry;

   Sammanfattning : The main focus of this thesis is on the aromaticity of the ground state and electronically excited states of π-conjugated molecules and polymers, as well as how aromaticity is connected to their properties.The electronic structures of polybenzenoid hydrocarbons (PBHs) were explored through density functional theory (DFT) calculations and the π-component of the electron localization function (ELFπ). LÄS MER

3. 17. Of spiders, bugs, and men : Structural and functional studies of proteins involved in assembly

   Författare :Wangshu Jiang; Stefan D Knight; Steve J. Matthews; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein assembly; sulfate transporter; crystallography; Proteus mirabilis; fimbriae; adhesin; urinary tract infection; biofilm; spider silk; asymmetric dimer; Bri2; BRICHOS; molecular chaperone; Alzheimer s disease; amyloid; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi;

   Sammanfattning : Protein assembly enables complex machineries while being economical with genetic information. However, protein assembly also constitutes a potential threat to the host, and needs to be carefully regulated.Sulfate is a common source of sulfur for cysteine synthesis in bacteria. LÄS MER

4. 18. Targeting Infectious Disease : Structural and functional studies of proteins from two RNA viruses and Mycobacterium tuberculosis

   Författare :Anna M. Jansson; T. Alwyn Jones; Sherry L. Mowbray; E. Yvonne Jones; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; RNA virus; coronavirus; alphacoronavirus; nsp1; TGEV; flavivirus; Modoc virus; NS5; methyltransferase; mRNA capping; Mycobacterium tuberculosis; tuberculosis; 1-deoxy-D-xylulose 5-phosphate reductoisomerase; DXR; fosmidomycin analogues; MEP pathway; drug development; xray-crystallography; Biology with specialization in Structural Biology; Biologi med inriktning mot strukturbiologi; Biology with specialization in Molecular Biology; Biologi med inriktning mot molekylärbiologi; Biokemi; Biochemistry; Medicinal Chemistry; Läkemedelskemi;

   Sammanfattning : The recent emergence of a number of new viral diseases as well as the re-emergence of tuberculosis (TB), indicate an urgent need for new drugs against viral and bacterial infections.Coronavirus nsp1 has been shown to induce suppression of host gene expression and interfere with host immune response. LÄS MER

5. 19. Deciphering molecular mechanisms in the evolution of new functions

   Författare :Hind Abdalaal; Joakim Näsvall; Paul Rainey; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Evolvability; functional trade-offs; collateral toxicity; duplication and amplification; Biologi med inriktning mot mikrobiologi; Biology with specialization in Microbiology; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution;

   Sammanfattning : The evolution of new genes and functions is considered to be a major contributor to biological diversity in organisms. Through de novo origination, “duplication and divergence”, and horizontal gene transfer, organisms can acquire new genetic material that can evolve to perform novel functions. LÄS MER

7. 20. Functional Polymer Electrolytes for Multidimensional All-Solid-State Lithium Batteries

   Författare :Bing Sun; Daniel Brandell; Kristina Edström; Michel Armand; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Polymer electrolyte; Li-battery; 3D-microbattery; Functionalization; Polyether; Polycarbonate; Copolymer; Kemi med inriktning mot materialkemi; Chemistry with specialization in Materials Chemistry;

   Sammanfattning : Pressing demands for high power and high energy densities in novel electrical energy storage units have caused reconsiderations regarding both the choice of battery chemistry and design. Practical concerns originating in the conventional use of flammable liquid electrolytes have renewed the interests of using solvent-free polymer electrolytes (SPEs) as solid ionic conductors for safer batteries. LÄS MER