Sökning: "functional genomics"

Visar resultat 21 - 25 av 116 avhandlingar innehållade orden functional genomics.

  1. 21. Genomics of Plasmodiophora brassicae

    Författare :Suzana Stjelja Arvelius; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : Plasmodiophora brassicae is a soil-borne pathogen that infects roots of plants in Brassicaceae and causes enlarged roots or clubs known as the clubroot disease. Details of its complex life cycle and particularly the molecular basis of its strategies to master defenses and alter metabolism of plant hosts are still largely unknown. LÄS MER

  3. 22. A functional genomics approach to study prostate disorders

    Författare :See-Tong Pang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Prostate cancer; BPH; androgen; DNA microarray; gene expression; CGH; SKY; oxidative stress.;

    Sammanfattning : Benign prostate hyperplasia (BPH) and prostate cancer (PCa) are the two most common prostatic disorders in elderly man. Currently, the causes of both diseases are still not clear. However, androgen is a well recognized risk factor for both diseases. LÄS MER

  4. 23. A functional genomics approach to PDGF and pericyte biology

    Författare :Cecilia Bondjers; Göteborgs universitet; []
    Nyckelord :PDGF; hair follicle; skin; testis; epithelial-mesenchymal interaction; microarray; pericyte; transgenic mouse;

    Sammanfattning : The rapid expansion of genome sequence data demands for increased efforts and speed concerning functional analysis of gene products. Two approaches to such analysis, namely transgenic technologies and analysis of gene expression have successfully been used to study functions of gene products in complex organisms, such as mammals. LÄS MER

  5. 24. Exploring human variations by droplet barcoding

    Författare :Pontus Höjer; Afshin Ahmadian; Pelin Sahlén; Lars Feuk; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; droplets; linked-read sequencing; DNA barcoding; proteomics; genomics; single cell; single extracellular vesicle; single exosome; pipelines; Biotechnology; Bioteknologi;

    Sammanfattning : Biological variations are being explored at ever-increasing rates through the rapid advancement of analytical techniques. Techniques like massively parallel sequencing empower scientists to accurately differentiate individuals’ genetic compositions, cellular functionalities, and healthy tissue from diseased. LÄS MER

  7. 25. Transcriptome and Proteome Analysis using Signature Tags

    Författare :Charlotta Agaton; KTH; []
    Nyckelord :functional genomics; 3´-end signature tags; pyrosequencing; amplification; PrEST; chromosome 21; polyclonal antibodies; dual expression; affinity purification;

    Sammanfattning : With the full sequence of the human genome now available, anexciting era in biomedical research has started. The sequenceprovides information about all our genes and greatly increasesthe scope to compare genetic activities in different cells, toanalyze genetic variation between individuals and betweendifferent species and, most importantly, to investigatesystematically the whole genome in a gene-by-gene manner, andthus increase our understanding of gene function. LÄS MER