Sökning: "fria fettsyror"

Visar resultat 1 - 5 av 17 avhandlingar innehållade orden fria fettsyror.

  1. 1. Short- and long-term effects of long-chain free fatty acids on pancreatic α- and β-cell function

    Författare :Charlotta Olofsson; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; diabetologi; sekretion; Endokrinologi; diabetology; secreting systems; Endocrinology; type-2 diabetes.; intracellular free Ca2 ; exocytosis; Free fatty acids; pancreatic α- and β-cells;

    Sammanfattning : We have investigated the in vitro effects of long-chain free fatty acids (FFAs) on mouse pancreatic α- and β-cells by a combination of electrophysiological recordings, intracellular Ca2+ ([Ca2+]i) microfluorimetry and hormone release measurements. Acute addition of the saturated FFA palmitate to intact islets doubled insulin as well as glucagon secretion in the presence of 1 or 15 mM glucose and the FFA remained capable of enhancing release of both hormones in islets depolarised with high K+ in the presence of the KATP channel opener diazoxide, indicating that alterations of ATP sensitive potassium (KATP) channel activity is not part of the effect. LÄS MER

  3. 2. ALPHA-LINOLENIC ACID Postprandial Lipid Metabolism and Enzymatic Interesterification of Triacylgylcerols

    Författare :Julia Svensson; Bioteknik; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; alpha-linolenic acid; triacylglycerol; postprandial lipemia; Lipozyme TL IM; interesterification;

    Sammanfattning : An important indicator of the metabolic capacity of humans is the ability to regulate plasma triacylglycerol levels and to clear triacylglycerol-rich lipoproteins (TRLs) from the circulation after a meal. This is crucial since most of the day is spent in the postprandial state. LÄS MER

  4. 3. Search for molecular and metabolic mechanisms contributing to impaired β-cell function

    Författare :Siri Malmgren; Diabetes - epigenetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIF-1α; oxygen consumption; β-cell; Insulin secretion; Type 2 Diabetes; mitochondrial metabolism; metabolic profiling; Lipotoxicity; Histone acetylation; Histone methylation;

    Sammanfattning : Type 2 Diabetes (T2D) prevalence is growing to pandemic proportions worldwide. The link between genotype, environment and β-cell function is still being investigated. LÄS MER

  5. 4. Common variants in genes regulating free fatty acid metabolism and risk of type 2 diabetes and cardiovascular disease

    Författare :Martin Carlsson; Malmö Institutionen för kliniska vetenskaper; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cardiovascular disease; free fatty acids; genetics; UCP1; beta3-adrenergic receptor; beta2-adrenergic receptor; type 2 diabetes mellitus; FABP2; stroke; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi;

    Sammanfattning : Abstract The present study evaluated genetic and metabolic factors influencing the risk for type 2 diabetes and cardiovascular disease (CVD) with special reference to increased concentrations of free fatty acids (FFA) in 1174 Swedish diabetic and nondiabetic subjects. Common polymorphisms in the fatty acid binding protein 2 (FABP2), the B2-adrenergic receptor (B2-AR), the B3 -adrenergic receptor (B3-AR) and the uncoupling protein 1 (UCP-1) genes were related to anthropometric and metabolic variables. LÄS MER

  7. 5. Den humana mjölkens lipaser : egenskaper och fysiologiska aspekter

    Författare :Olle Hernell; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : I avhandlingen visas att: Human mjölk innehåller två lipaser. Det ena är ett serum-stimulerat lipas (lipoprotein lipas). Lipoprotein lipaser är enzymer som har en central roll i den normala katabolismen av de triglyceridrika plasma- lipoproteinerna. Lipaset har sannolikt inte någon fysiologisk funktion i mjölken. LÄS MER