Sökning: "free radical scavenging"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden free radical scavenging.

  1. 1. Mechanisms of Brain Damage Following Focal Cerebral Ischemia: Changes in Ion Homeostasis and the Importance of Free Radical Formation

    Författare :Gunilla Gidö; Sektion IV; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PBN; free radicals; potassium; extracellular calcium; neuronal damage; energy-depletion; hypoglycemia; Cerebral focal ischemia; spreading depression; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Sammanfattning : In this thesis mechanisms of neuronal damage were investigated in an experimental stroke model i.e focal ischemia. The influence of SD-induced calcium transients on neuronal damage were studied in animals with reduced energy supply. LÄS MER

  3. 2. Delayed Cell Death after Traumatic Brain Injury : Role of Reactive Oxygen Species

    Författare :Fredrik Clausen; Lars Hillered; Tiit Mathiesen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Traumatic Brain Injury; Reactive oxygen species; Fluid percussion injury; Controlled cortical impact; weight drop injury; Extracellular-signal regulated kinase; apoptosis; free radical scavenging; morphology; functional outcome; Neurovetenskap; Neurology; Neurologi;

    Sammanfattning : Traumatic brain injury (TBI) is a leading cause of death and disability TBI survivors often suffer from severe disturbances of cognition, memory and emotions. Improving the treatment is of great importance, but as of yet no specific neuroprotective treatment has been found. LÄS MER

  4. 3. A1M: a heme and radical binding protein. A study on structure, function and mechanisms

    Författare :Sigurbjörg Rutardottir; Infektionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; α1-microglobulin; oxidative stress; heme; radiation; reactive oxygen species; preeclampsia;

    Sammanfattning : This thesis describes functional and structural studies of the human protein α1-microglobulin (A1M), an evolutionarily well-conserved 26 kDa plasma and tissue protein mainly synthesized in the liver. A1M belongs to the lipocalin protein family. Lipocalins share a very similar structur, an 8-stranded β-barrel forming a hydrophobic pocket. LÄS MER

  5. 4. Structure function studies of ribonucleotide reductase from Escherichia coli

    Författare :Åke Larsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The enzyme ribonucleotide reductase from Escherichia coliconsists of the two proteins, Bl and B2.To construct an efficient overproduction system for Bl, the nrdAgene, coding for the Bl protein was moved from a pBR322derivative into a plasmid that contains a temperature-sensitivecopy number control. LÄS MER

  7. 5. Novel lipid derivatives for health benefits : synthesis, analysis and effects in diet-induced obese mice

    Författare :Samanthi Madawala; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : Obesity is a public health concern and requires effective management with multiple approaches. Dietary supplements of bioactive compounds that can improve fatty acid oxidation and thermogenesis are currently in focus to develop anti-obese food ingredients/nutraceuticals without side-effects. LÄS MER