Sökning: "free oxygen radicals"

Visar resultat 16 - 20 av 63 avhandlingar innehållade orden free oxygen radicals.

  1. 16. Hyperreactive peripheral neutrophils in periodontitis : FCc receptor activation and plasma proteins

    Författare :Margareta Fredriksson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Periodontitis neutrophils; oxygen radicals; smoking; priming.;

    Sammanfattning : It is now well established that adult and juvenile periodontitis are associated with a hyperreactivity of the peripheral neutrophils when measured as increased generation of free oxygen radicals after stimulation of the Fcgamma-receptors. Aim: The aims of these investigations were to study if the increased radical generation was: 1) located intra- or extracellularly and attributed to a specific oxygen species or various activation pathways, 2) connected with "priming" (pre-stimulation only disclosed by a secondary activation), 3) associated with systemic aberrations in plasma parameters induced by the periodontal disease or cigarette smoking or 4) related to the neutrophil production of the cytokines IL-8 and TNFalpha after stimulation. LÄS MER

  3. 17. Radical aspects on arthritis : the role of neutrophil generation of nitric oxide and superoxide in inflammatory conditions

    Författare :Jan Cedergren; Thomas Skogh; Tommy Sundqvist; Tony Forslund; Ingrid Lundberg; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neutrophils; reactive oxygen species; arthritis; NOS; NO; arginase; integrins; Internal medicine; Invärtesmedicin;

    Sammanfattning : The polymorphonuclear neutrophil granulocytes (neutrophils) are gaining renewed interest regarding their involvement in chronic inflammatory disorders, including rheumatoid arthritis (RA). Besides phagocytic and destructive capabilities, neutrophils have regulatory roles, e.g. by influencing responses from dendritic cells and lymphocytes. LÄS MER

  4. 18. Pituitary adenylate cyclase activating polypeptide : Expression and neurotrophic activity in the rat brain

    Författare :Ylva Skoglösa; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; in situ hybridisation; rat; TBI; BDNF; NGF; GDNF; PACAP; PRI; TUNEL; apoptosis; CNS; PNS; neuropeptides; neurotrophic factors; reactive oxygen species; Neurovetenskap; Neurology; Neurologi; Neurology; neurologi;

    Sammanfattning : Neurotrophic factors play an important role in regulating naturally occurring cell death during neurogenesis. In addition to classical neurotrophic factors, some neurotransmitters and neuropeptides have been shown to exhibit neurotrophic activities. LÄS MER

  5. 19. Mechanisms of traumatic brain injury in the rat : Morphological consequences and neurotrophic responses

    Författare :Anders Lewén; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Cortical contusion injury; TBI; neurons; axons; dendrites; APP; MAP2; BMPR-II; ActR-I; trkB; c-fos; BDNF; PACAP; TUNEL; TGFs; serine threonine; bone morphogenetic protein; neuropeptides; reactive oxygen species; ROS; apoptosis; Neurovetenskap; Neurology; Neurologi; Neurosurgery; neurokirurgi;

    Sammanfattning : Traumatic brain injury is a major cause of death and disability in the Western world. especially in young people. Understanding the pathophysiology of traumatic brain injury is the basis for further development of better therapeutic strategies for such patients. LÄS MER

  7. 20. Impact of sepsis and HIV-1 infection on neutrophil radical production, lipids and lipoproteins

    Författare :Börje Åkerlund; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :sepsis; HIV-1 infection; lipoprotein changes; free oxygen radicals; neutrophils; lipidperoxidation; oxidative stress; N-acetylcysteine;

    Sammanfattning : In clinical sepsis a decrease in total serum cholesterol caused by reduced HDL and LDL cholesterol occurred early in the course of the infection with a normalisation after 2 months. This "sepsis HDL" was shown to contain the acute phase reactant SAA and it affected several functions of the neutrophil. LÄS MER