Sökning: "fredrik lennmyr"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden fredrik lennmyr.

  1. 1. Signal Transduction in Focal Cerebral Ischemia : Experimental Studies on VEGF, MAPK and Src family kinases

    Författare :Fredrik Lennmyr; Andreas Terént; Tommy Olsson; Uppsala universitet; []
    Nyckelord :Medical sciences; MEDICIN OCH VÅRD; MEDICINE; MEDICIN; Medicin; Medicine;

    Sammanfattning : Cerebral ischemia elicits a wide range of events, including complex activation of various intracellular signaling pathways. This study aims to investigate the expression of vascular endothelial growth factor (VEGF) and the activation pattern of mitogen-activated protein kinases (MAPK) in reponse to focal cerebral ischemia. LÄS MER

  3. 2. Hyperglycemia and Focal Brain Ischemia : Clinical and Experimental Studies

    Författare :Nasim Farrokhnia; Andreas Terént; Fredrik Lennmyr; Elisabeth Björk; Henrik Hagberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Internal medicine; cerebrovascular disorders; diabetes mellitus; hyperglycemia; infarction; middle cerebral artery; ischemia; mitogen-activated protein kinases; mortality; rats; reactive oxygen species; reperfusion; signal transduction; therapeutics; Invärtesmedicin; Internal medicine; Invärtesmedicin;

    Sammanfattning : Diabetes is a major risk factor for ischemic stroke and is associated with increased mortality. Additionally, hyperglycemia, a common complication in acute stroke, is associated with poor outcome. LÄS MER

  4. 3. Cerebral Perfusion and Metabolism during Experimental Extracorporeal Circulation

    Författare :Ove Jonsson; Stefan Thelin; Fredrik Lennmyr; Sven-Erik Ricksten; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cerebral perfusion; Experimental brain research; Experimentell hjärnforskning; Thoraxkirurgi; Thorax Surgery;

    Sammanfattning : Neurologic injuries are major causes of mortality and morbidity after cardiac surgery. This thesis aimed to investigate cerebral metabolism and perfusion abnormalities in pigs during hypothermic circulatory arrest, selective antegrade cerebral perfusion (SACP) and extracorporeal circulation following progressive venous stasis. LÄS MER

  5. 4. Hyperglycemia in Experimental Cerebral Ischemia

    Författare :Maria Molnar; Fredrik Lennmyr; Sten Lindahl; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; brain ischemia; cardiac arrest; cytokines; gene expression; glucose; hyperglycemia; microarray; oxidative stress; pigs; rats; reperfusion; resuscitation S100β; Anaesthesiology and Intensive Care; Anestesiologi och intensivvård; Neuroscience; Neurovetenskap;

    Sammanfattning : Cerebral ischemia is a life-threatening condition associated with a substantial morbidity and mortality. Hyperglycemia, a common coexisting phenomenon in both stroke and cardiac arrest (CA), may further aggravate ischemic brain injury. To date, the therapeutic possibilities are lim-ited and the search for new treatment modalities is warranted. LÄS MER

  7. 5. Cerebral Perfusion during Cardiopulmonary Bypass

    Författare :Thomas Tovedal; Fredrik Lennmyr; Stefan Thelin; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Impaired superior vena cava (SVC) cannula outflow during cardiopulmonary bypass (CPB) is a frequent issue, often manifested by only marginal changes in routine monitoring parameters. Nevertheless, significant impact on cerebral perfusion may result. LÄS MER