Sökning: "fredrik larsson"

Visar resultat 21 - 25 av 52 avhandlingar innehållade orden fredrik larsson.

  1. 21. Antiadhesive agents targeting uropathogenic Escherichia coli : Multivariate studies of protein-protein and protein-carbohydrate interactions

    Författare :Andreas Larsson; Jan Kihlberg; Fredrik Almqvist; Mats Larhed; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Antibacterial; pili; antiadhesive agents; structure based design; statistical molecular design; 2-pyridone; amino acid derivative; galabiose; enaminone; SPR; ELISA; QSAR; Organisk kemi; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : This thesis describes studies directed towards development of novel antiadhesive agents, with particular emphasis on compounds that prevent attachment of bacteria to a host-cell. Three different proteins involved in the assembly or function of adhesive pili in uropathogenic Escherichia coli have been targeted either by rational structure based design or statistical molecular methods. LÄS MER

  3. 22. Integrative modeling of intratumoral heterogeneity, plasticity and regulation in nervous system cancers

    Författare :Ida Larsson; Sven Nelander; Fredrik Swartling; Patrik Johansson; Itay Tirosh; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Nervous system cancer; Glioblastoma; Heterogeneity; Plasticity; Mathematical modeling; Oncology; Onkologi;

    Sammanfattning : The adult brain tumor glioblastoma (GBM) is characterized by short survival and a lack of efficient treatments. Median survival is 15 months from time of diagnosis and the 5-year survival rate is only 7 %. LÄS MER

  4. 23. Molecular mechanisms of modulation of KV7 channels by polyunsaturated fatty acids and their analogues

    Författare :Johan Larsson; Sara Liin; Fredrik Elinder; Maurizio Taglialatela; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Ion channels are membrane proteins that regulate the permeability of ions across the cell membrane. The sequential opening of different types of ion channels produces action potentials in excitable cells. Action potentials are a way for the body to, for example, transmit signals quickly over a long distance. LÄS MER

  5. 24. The Governmentality of Meta-governance : Identifying Theoretical and Empirical Challenges of Network Governance in the Political Field of Security and Beyond

    Författare :Oscar Larsson; PerOla Öberg; Fredrik Bynander; Stefano Guzzini; Lars Niklasson; Uppsala universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; meta-governance; meta-governance stance; governance; governmentality; sovereign power; political power; networks; security; communications systems; process-tracing; interpretive policy analysis; Sweden; KBM; MSB; RAKEL; Statskunskap; Political Science;

    Sammanfattning : Meta-governance recently emerged in the field of governance as a new approach which claims that its use enables modern states to overcome problems associated with network governance. This thesis shares the view that networks are an important feature of contemporary politics which must be taken seriously, but it also maintains that networks pose substantial analytical and political challenges. LÄS MER

  7. 25. Key Elements of Software Product Integration Processes

    Författare :Stig Larsson; Ivica Crnkovic; Fredrik Ekdahl; Rikard Land; Paul Grünbacher; Mälardalens högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; product integration; software development; process improvement; Software engineering; Programvaruteknik; Computer Science; datavetenskap;

    Sammanfattning : The product integration is a particularly critical phase of the software product development process as many problems originating from earlier phases become visible in this phase. Problems in product integration result in delays and rework. LÄS MER