Sökning: "fragmentation mechanism"

Visar resultat 21 - 25 av 65 avhandlingar innehållade orden fragmentation mechanism.

  1. 21. An experimental study on the dynamics of melt-water micro-interactions in a Vapor explosion

    Författare :Roberta Concilio Hansson; Truc-Nam Dinh; Daniel Magallon; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Nuclear physics; Kärnfysik;

    Sammanfattning : Vapor explosion as a result of Molten Fuel-Coolant Interactions (MFCI) postulated to occur in certain severe accident scenarios in a nuclear power plant presents a credible challenge on the plant containment integrity. Over the past several decades, a large body of literature has been accumulated on vapor explosion phenomenology and methods for assessment of the related risk. LÄS MER

  3. 22. Method and technique development in peptide and protein mass Spectrometry

    Författare :Kristina Håkansson; Uppsala universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Materials science; electrospray ionization; peptide sequencing; Fourier transform ion cyclotron resonance; hydrogen deuterium exchange; protein structure; Materialvetenskap; Materials science; Teknisk materialvetenskap; Molecular Biotechnology; Molekylär bioteknik;

    Sammanfattning : Mechanistic studies and applicability of several methods and techniques for studying peptides and proteins with mass spectrometry are presented. A model for the protein molecular ion formation in explosive matrix-assisted plasma desorption mass spectrometry is proposed, involving a contribution from the chemical energy release during conversion of the explosive, an enhanced protonation through collisions with products from the explosive decay, and electron scavenging by other products. LÄS MER

  4. 23. Analyses of Dose-Response and Mechanistic Action of Different Anti-Cancer Drugs for Neuroendocrine Tumor Cell Lines

    Författare :Dhana E Larsson; Dan Granberg; Sadia Hassan; Kjell Öberg; Jens F Rehfeld; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cancer drugs; Screening; Hollow Fiber model; Apoptosis; Oncology; Onkologi;

    Sammanfattning : Cancer is a disease with poor response rates on available treatments. Problems with resistance and intolerance against cancer drugs are major reasons for failure of the drugs. The need to discover new cancer drugs is important. In this thesis screening of new cancer drugs and evaluation of their mechanism of action are discussed. LÄS MER

  5. 24. Quaternary structure and interaction approaches to allosteric regulation of class I ribonucleotide reductases

    Författare :Mikael Crona; Britt-Marie Sjöberg; Mark Meuth; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ribonucleotide reductase; allosteric regulation; quaternary structure; subunit interactions; enzyme activity; SPR; GEMMA; Molecular biology; Molekylärbiologi; Molecular Biology; molekylärbiologi;

    Sammanfattning : Deoxyribonucleic acid (DNA) chains in which our genetic blueprint is stored are built from four DNA precursors by DNA polymerases. The enzyme ribonucleotide reductase (RNR) provides the only de novo synthesis pathway of deoxyribonucleotides from ribonucleotides and is essential for nearly all organisms. LÄS MER

  7. 25. Regulation of T cell apoptosis by calcium and zinc ions

    Författare :Shunai Jiang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Apoptosis is a major form of cell death involved in fundamental processes in the mammalian immune system. Although extensive studies have been carried out to explore the mechanisms involved in lymphocyte apoptosis, a defined signaling pathway is still unclear. LÄS MER