Sökning: "fractionation sensitivity"
Visar resultat 1 - 5 av 17 avhandlingar innehållade orden fractionation sensitivity.
1. Searching for the optimal radiotherapy treatment time, dose and fractionation - the role of hypoxia and reoxygenation : A modelling study
Sammanfattning : The search for the optimal choice of treatment time, dose and fractionation regimen is one of the major challenges in radiation therapy. Several aspects of the radiation response of tumours and normal tissues give different indications of how the parameters defining a fractionation schedule should be altered relative to each other which often results in contradictory conclusions. LÄS MER
2. Radiobiological end-points for the theoretical evaluation of the effectiveness of carbon ions and photons in treating tumours with dynamic hypoxia
Sammanfattning : Tumours are characterised by unorganised vasculature, which often results in hypoxic regions. Hypoxia is a common cause for photon radiotherapy (RT) treatment failure, as hypoxic cells require up to 2-3 times higher doses compared to well-oxygenated cells for the same effect in terms of cell kill. LÄS MER
3. Modelling late toxicity in hypofractionated radiation therapy
Sammanfattning : In hypofractionated radiation therapy (RT), the treatment is delivered by few fractions with high doses per fraction. This is in contrast to conventionally fractionated RT where the total dose is delivered in many fractions with low doses per fraction. LÄS MER
4. Isotope Ratio and Trace Element Measurements Using Inductively Coupled Plasma – Mass Spectrometry : Method Development and Applications in Environmental Forensics
Sammanfattning : Environmental Forensics is a scientific methodology developed for identifying sources, the timing of release, and transport pathways for potentially hazardous environmental contaminants. It combines a variety of analytical methods with principles derived from disciplines such as chemistry, geology, geochemistry, hydrogeology, and statistics, with the purpose to provide objective scientific and legal conclusions on the source and/or time of a contaminant release. LÄS MER
5. Mass spectrometry-based proteomic strategies applied to Helicobacter pylori. A Search for candidate vaccine antigens
Sammanfattning : This thesis describes the development and refinement of proteomic strategies and the application of these on the human gastric pathogen H. pylori. The purpose was to identify proteins, and in particular membrane proteins, as potential targets for vaccine development. LÄS MER