Sökning: "founder virus"

Hittade 5 avhandlingar innehållade orden founder virus.

  1. 1. Viral dynamics and evolution following primary HIV-1 infection

    Författare :Annika C Karlsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1; primary infection; diversity; divergence; env; gag; pol; viral load; RNA; DNA; resting CD4 T-lyrnphocytes; antiretroviral resistance; founder virus; latency; PCR; cloning; sequencing;

    Sammanfattning : The knowledge of the early events during primary HIV-1 infection (PER) is of great importance for the understanding of the pathogenesis of HIV-1. A major problem in studies on PHI is the limited amount of data accessible from the early time-points. LÄS MER

  3. 2. Phylogenetic and phenotypic properties of HIV-1 variants of different subtypes, in mother to child transmission

    Författare :Rozina Caridha; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Transmission from mother to child is the most common way that children contract HIV-1 infection in developing countries; transmission through this route is prevented in most developed countries by antiretroviral treatment, elective Caesarean section and absence of breast-feeding. However, these measures are not fully available in developing countries. LÄS MER

  4. 3. Aspects on latency in HIV-1 infection

    Författare :Annica Lindkvist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The use of combination antiretroviral therapy (ART) has resulted in a substantial reduction in viremia, a rebound of CD4+ T-cells and increased survival for human immunodeficiency virus type 1 (HIV-1) infected individuals. Unfortunately, ART does not clear the infection or cure the individual from HIV-1. LÄS MER

  5. 4. The HIV-1 epidemic in Ethiopia – transmission patterns, antiretroviral drug resistance and treatment outcomes

    Författare :Dawit Assefa; Malmö Klinisk virologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV-1; HIV drug resistance HIVDR ; Phylodynamics; Phylogenetic; Molecular epidemology; transmitted HIVDR; acquired HIVDR; pre-treatment HIVDR; Integrase strand transfer inhibitors INSTI ; Ethiopia; antiretroviral therapy;

    Sammanfattning : A comprehensive understanding of local HIV epidemiology is essential for monitoring transmission, designing, implementing, and evaluating HIV intervention strategies. In paper I, we used a total of 1276 HIV-1 subtype C pol sequences and employed state-of-art phylogenetic and phylodynamic tools to describe the molecular epidemiology of HIV in Ethiopia. LÄS MER

  7. 5. Complement activation - good or evil in HIV-1 infection? : interaction of free and complement opsonized HIV-1 with monocyte derived dendritic cells and immune cells in the cervical mucosa

    Författare :Veronica Tjomsland; Marie Larsson; Jorma Hinkula; Karl-Eric Magnusson; Barbara Shacklett; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Worldwide, the heterosexual route is the most common mode of sexual transmission of HIV-1 and women are particularly susceptible to this infection. After penetration of the mucosal epithelium HIV-1 interacts with potential target cells, i.e. dendritic cells (DCs) and CD4+ T cells. LÄS MER