Sökning: "founder effect"

Visar resultat 1 - 5 av 33 avhandlingar innehållade orden founder effect.

  1. 1. Genetic and Molecular analysis of the Spinocerebellar ataxia type 7 (SCA7) disease gene

    Författare :Jenni Jonasson; Monica Holmberg; Christine Van Broeckhoven; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Spinocerebellar ataxia; human genetics; linkage analysis; anticipation; CAG repeat expansion; founder effect; protein expression; ATXN7; Medical genetics; Medicinsk genetik;

    Sammanfattning : Spinocerebellar ataxia type 7 (SCA7) is a hereditary neurodegenerative disorder affecting the cerebellum, pons and retina. SCA7 patients present with gait ataxia and visual impairment as the main symptoms. LÄS MER

  3. 2. Hereditary transthyretin amyloidosis (ATTR V30M) : from genes to genealogy

    Författare :Nina Norgren; Ole Suhr; Alda Sousa; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hereditary transthyretin amyloidosis; Familial amyloid polyneuropathy; transthyretin; genealogy; founder effect; miRNA; allele-specific expression; gene expression; liver; medicin; Medicine;

    Sammanfattning : Background: Hereditary transthyretin amyloidosis is an autosomal dominant disease with a reduced penetrance. The most common mutation in Sweden is the V30M mutation in the transthyretin gene. Clustering areas of the disease can be found in Northern Sweden, Portugal, Brazil and Japan, although sporadic cases exist worldwide. LÄS MER

  4. 3. Quantitative genetic variation in declining plant populations

    Författare :Maarten Ellmer; Biologiska institutionen; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Saxifraga granulata; Briza media; Nigella degenii; bottleneck; Inbreeding depression; founder effects; drift; quantitative genetic; diversifying selection; habitat fragmentation; small populations;

    Sammanfattning : The ecological and genetic effects of habitat fragmentation are an issue of major concern in current conservation biology. Habitat fragmentation results in smaller habitat areas and as a consequence smaller and more isolated populations. Many habitats have become fragmented through human activities such as forestry and agricultural development. LÄS MER

  5. 4. Predicting who stays or leaves after the acquisition: : Target’s top manager turnover

    Författare :Keivan Aghasi; Terrence Brown; Massimo Colombo; Maureen McKelvey; KTH; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Acquisition; CEO turnover; TMT turnover; coordination; Founder-CEO; Similarity attraction; Diversity;

    Sammanfattning : In acquisition of high-tech and knowledge intensive firms, scholars have paid special attention to top managers’ status after the deal. Literature suggests that these managers in particular CEOs if kept in post-acquisition provide coordination capacity for the acquirer to transfer the knowledge and technology from the target to the acquirer while minimizing the disruptive effect of post-acquisition integration process. LÄS MER

  7. 5. Essays on Corporate Finance and Asset Pricing

    Författare :Jon Frank; Mikael Bask; Lars Forsberg; Dušan Isakov; Uppsala universitet; []
    Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Corporate Finance; Asset Pricing; Founding family firms; Firm performance; Firm financing; Firm investments; Stock returns; Stock-bond correlation;

    Sammanfattning : Essay 1 (with Mattias Hamberg): We study the performance of family firms with large controlling owners using unique hand-collected Swedish data; and consistent with previous studies, we find that founding family firms perform significantly better than other firms. The data allows us to also identify firms with long term non-founding owners (LTNFOs). LÄS MER