Sökning: "formylation"

Hittade 3 avhandlingar innehållade ordet formylation.

  1. 1. Mechanisms of Adaptation to Deformylase Inhibitors

    Författare :Anna Zorzet; Dan Andersson; Paul Rainey; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; antibiotic resistance; compensatory evolution; compensatory mutations; protein synthesis; initiation factor 2; initiator tRNA; formylation; peptide deformylase inhibitors; Bacteriology; Bakteriologi; Mikrobiologi; Microbiology; Biokemi; Biochemistry; Geography; Geografi;

    Sammanfattning : Antibiotic resistance is a growing problem on a global scale. Increasing numbers of bacteria resistant toward one or multiple antibiotics could return us to the high mortality rates for infectious diseases of the pre-antibiotic era. LÄS MER

  3. 2. Palladium-promoted synthesis of compounds labelled with ¹¹C : Synthesis of ¹¹C-labelled prostacyclin and prostaglandin analogues

    Författare :Margareta Björkman; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Kemi; Chemistry; Kemi; organisk kemi; Organic Chemistry;

    Sammanfattning : Palladium-promoted reactions have been employed for the synthesis of compounds labelled with 11C (t½ = 20.3 min). The precursor [11C]methyl iodide was used in palladium-promoted cross-coupling reactions with organostannanes. LÄS MER

  4. 3. Synthesis of indole and oxindole derivates incorporating pyrrolidino, pyrrolo or imidazolo moieties

    Författare :Stanley Rehn; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Isatin; three-component reaction; a-amino acid; azomethine ylide; pyrrolidino-3-spiro-3?-oxindole derivatives; 3-methyleneoxindole derivatives; pyrroloquinolone; TosMIC; ß-carboline; tosylimine; pyrrole; keto-enol tautomerism; indolopyran-2-one; imidazole; benzylimine; tetrahydroindole;

    Sammanfattning : The focus of this thesis is on the synthesis of oxindole- and indole-derivatives incorporating pyrrolidins, pyrroles or imidazoles moieties. Pyrrolidino-2-spiro-3'-oxindole derivatives have been prepared in high yielding three-component reactions between isatin, alpha-amino acid derivatives, and suitable dipolarophiles. LÄS MER