Sökning: "forkhead"

Visar resultat 21 - 25 av 36 avhandlingar innehållade ordet forkhead.

  1. 21. Neuromodulation, Short-Term and Long-Term Plasticity in Corticothalamic and Hippocampal Neuronal Networks

    Författare :Sofie Sundberg; Björn Granseth; Fredrik Elinder; Eric Hanse; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Research in neuroscience relies to a large extent on the use of genetically modified animals. Extensive validation of new and existing models is a requirement for the acquisition of trustworthy data and to enable generalization to human physiology and disease. LÄS MER

  3. 22. Foxi1, an important gene for hearing, kidney function and male fertility

    Författare :Hilmar Vidarsson; Göteborgs universitet; []
    Nyckelord :;

    Sammanfattning : Aim: In this study we focused on the biological importance of the forkhead transcription factor Foxi1. The overall aim was to elucidate the functional role of Foxi1 in the inner ear, kidney and epididymis. LÄS MER

  4. 23. Regulation of IL-6-signaling and inflammatory response – Role of insulin, FOXO1 and PKCδ

    Författare :Emelie Wallerstedt; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 2-Diabetes; inflammation; obesity; IL-6; STAT3; PKCδ; FOXO1;

    Sammanfattning : The aim of this thesis was to investigate if and how insulin antagonizes interleukin-6 (IL-6)-signaling and action using both 3T3-L1 mouse adipocytes (Paper I) and HepG2 human hepatocytes (Paper III). We also investigated the importance of PKCδ in 3T3-L1 adipocytes and mouse embryonic fibroblasts (MEFs) lacking protein kinase C-δ (PKCδ-/-) (Paper II). LÄS MER

  5. 24. Transcriptional regulation of thyroid development possible interplay of endoderm- and mesoderm-derived morphogenetic signals

    Författare :Jessica Westerlund; Göteborgs universitet; []
    Nyckelord :thyroid; congenital hypothyroidism; dysgenesis; Tbx1; Shh; Isl1; Foxa2; C-cells;

    Sammanfattning : Congenital hypothyroidism (CH) affects 1 in 3000 children and is the major cause of treatable mental retardation. Most cases are due to malformations of the gland, collectively named thyroid dysgenesis. The disease results from defective thyroid organogenesis during embryonic life. LÄS MER

  7. 25. Profiling of Small Intestine Neuroendocrine Tumors

    Författare :Ellinor Andersson; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; small intestine neuroendocrine tumor; somatic copy number alteration; expression profiling; APLP1; survival; targeted therapy;

    Sammanfattning : Small intestine neuroendocrine tumors (SI-NETs) are malignant neoplasms usually presenting with disseminated disease and symptoms of hormone overproduction. Radical surgery is curative but can only be performed for localized disease. For most patients the disease follows a progressive and fatal course. LÄS MER