Sökning: "foregut endoderm"

Visar resultat 1 - 5 av 8 avhandlingar innehållade orden foregut endoderm.

  1. 1. Human Embryonic Stem Cells - Constitutive Gene Expression and Differentiation Towards Definitive Endoderm and Posterior Foregut Endoderm

    Författare :Karin Norrman; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; human embryonic stem cells; diabetes; pancreas; definitive endoderm; foregut endoderm; pancreatic endoderm; constitutive promoter; ACTB; EF1alpha; CMV; PGK; UbC;

    Sammanfattning : Abstract More than 300 million people are suffering from diabetes worldwide and the numbers of diabetic patients are increasing. Today´s treatments mainly rely on daily insulin injections. This help people to control blood glucose levels but still many patients suffer from the many complications associated with diabetes. LÄS MER

  3. 2. Human Embryonic Stem Cells: Directed Differentiation into Posterior Foregut Endoderm and a Functional Assay for Definitive Endoderm

    Författare :Martina Johannesson; Immunologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : A decade has passed since the first human embryonic stem cell (hESC) line was established, providing immense hope in curing diseases by cell replacement therapy. For instance, in the pancreas, the insulin-producing β-cells are damaged in diabetes patients, and a successful replacement of those cells could provide a cure. LÄS MER

  4. 3. FGF signaling in specification of hESC-derived definitive endoderm

    Författare :Jacqueline Ameri; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Diabetes affects around 200 million people worldwide. Curing diabetes would require the prevention of autoimmune destruction of beta cells and restoration of the beta cell mass restored either through regeneration or transplantation of the insulin producing cells. LÄS MER

  5. 4. The role of Lhx2 in the hematopoietic stem cell function, liver development and disease

    Författare :Ewa Wandzioch; Leif Carlsson; Stephen A Duncan; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; liver fibrosis; liver development; Lhx2; hematopoietic stem cells; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molecular cell biology; molekylär cellbiologi;

    Sammanfattning : During embryonic development, generation of functional organs is dependent on proper interactions between different cell types. Elucidation of the mechanisms operating during organ formation might provide insights into the origin of many pathological disorders in the adult. LÄS MER

  7. 5. Genetic analysis of ligand-receptor interactions in the TGF-beta superfamily during early embryonic development

    Författare :Olov Andersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : During early development, cells differentiate and acquire specific fates according to their position in concentration gradients of morphogens. These substances often spread from a local region, termed an organizer, and exert different effects at distinct thresholds. LÄS MER