Sökning: "follicular dendritic cells"
Visar resultat 16 - 20 av 25 avhandlingar innehållade orden follicular dendritic cells.
16. Exosomes : the future of vaccination?
Sammanfattning : Exosomes are small membrane vesicles that are secreted by cells as means of intercellular communication. They are typically between 50 and 100 nm in diameter and originate from the endosomal compartment of cells. Exosomes have been considered a potential novel cell- free therapeutic agent since exosomes are capable of antigen presentation. LÄS MER
17. The interplay between lipoproteins, immunity and tryptophan metabolism in atherosclerosis
Sammanfattning : Atherosclerotic cardiovascular disease (CVD) is the leading cause of mortality worldwide. Atherosclerosis is initiated by the infiltration and accumulation of low-density lipoprotein (LDL) cholesterol in the vascular wall, which activates the innate and adaptive arm of immunity, thereby causing chronic vascular inflammation. LÄS MER
18. Revealing the secrets of MARCO : a target for cancer immunotherapy
Sammanfattning : Our immune system protects us from infectious agents and sustains the homeostasis in our body. However, the immune system can also play a role in initiation and progression of diseases such as autoimmune diseases and cancer. Cancer is still one of the leading causes for death worldwide and inflammation became one of the hallmarks of cancer. LÄS MER
19. Fc receptors and feedback enhancement of antibody responses
Sammanfattning : Antibodies are important for the defence against microorganisms, but are also involved inpathological reactions such as allergy or autoimmunity. The exact mechanisms involved inregulation of antibody responses is still largely unknown. In this thesis, immune regulationby antibodies and the receptors they bind to (FcR), were investigated. LÄS MER
20. IgM and Complement in Regulation of Antibody Responses
Sammanfattning : Animals deficient in complement components C1q, C4, C3, and CR1/2 have severely impaired antibody responses. C1q is primarily activated by antibody-antigen complexes. Antigen-specific IgM in complex with an antigen is able to enhance the antibody response against that antigen. This is dependent on the ability of IgM to activate complement. LÄS MER