Sökning: "follicle-associated epithelium"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden follicle-associated epithelium.

  1. 1. Barrier function of the Follicle-Associated Epithelium in Stress and Crohn's disease

    Författare :Åsa Keita; Johan D. Söderholm; Ann-Charlott Ericson; Björn Weström; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Corticotropin-releasing hormone; Crohn’s disease; 51Cr- EDTA; Escherichia coli; follicle-associated epithelium; horseradish peroxidase; human; ileum; inflammatory bowel disease; intestinal mucosa; mast cell; M cell; permeability; Peyer’s patches; rat; Ussing chamber; vasoactive intestinal peptide; villus epithelium; Surgery; Kirurgi;

    Sammanfattning : Crohns sjukdom är en kronisk inflammatorisk tarmsjukdom av okänd orsak. Det tidigaste tecknet på Crohns sjukdom är mikroskopiska sår i det s.k. follikelassocierade epitelet (FAE) som täcker ansamlingar av immunceller i tarmen. LÄS MER

  3. 2. Mucosal dendritic cells in inflammatory bowel disease

    Författare :Sa'ad Yislam Salim; Johan D. Söderholm; Mary jo Wick; Linköpings universitet; []
    Nyckelord :Blood; Crohn s disease; dendritic cells; E. coli; FACS; follicle-associated; epithelium; human; ileum; mixed lymphocyte reaction; permeability; Peyer s patches; SAMP1 YitFc; Ussing chambers; villous epithelium; MEDICINE; MEDICIN;

    Sammanfattning : Crohn's disease, a chronic inflammation of the bowel, is a multi-factorial condition where uncontrolled immune responses to luminal bacteria occur in genetically predisposed individuals. The first observable clinical signs are small ulcers that form at a specialised form of epithelium, follicle-associated epithelium (FAB). LÄS MER

  4. 3. Effects of Microparticulate Drug Delivery Systems : Tissue Responses and Transcellular Transport

    Författare :Eva Ragnarsson; Per Artursson; Lucia Lazorova; David Brayden; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; microparticles; vaccine; pDNA vaccine; cationic polymer; gene expression analysis DNA array ; Caco-2; follicle-associated epithelium FAE ; M cell; transcytosis; Yersinia pseudotuberculosis; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Sammanfattning : Over the past decade, the development of macromolecular drugs based on peptides, proteins and nucleic acids has increased the interest in microparticulate drug delivery, i.e., the delivery of drug systems in the nanometer and micrometer ranges. LÄS MER

  5. 4. Particle Transcytosis Across the Human Intestinal Epithelium : Model Development and Target Identification for Improved Drug Delivery

    Författare :Elisabet Gullberg; Per Artursson; Barry Hirst; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; M-cell; FAE; Peyer´s patches; oral vaccination; uptake; endocytosis; Galenisk farmaci; Pharmaceutics; Galenisk farmaci;

    Sammanfattning : The use of nano- and micro-particulate carriers as delivery systems for oral vaccines has been under investigation for several decades. Surprisingly little is known of their uptake in the human intestine, despite the fact that substantial improvement is required to achieve adequate immune responses in man after oral administration. LÄS MER

  7. 5. Role of mast cells and probiotics in the regulation of intestinal barrier function

    Författare :Anders Carlsson; Johan D. Söderholm; Åsa Keita; Karl-Eric Magnusson; Björn Weström; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : The intestinal mucosa is the largest contact area and one of the most important barriers to the outside environment. It is highly specialized in aiding us digest and absorb nutrients. It is daily exposed to several potentially dangerous substances and microorganisms, which if they were allowed to pass into the body, could give rise to diseases. LÄS MER