Sökning: "focal adhesion complex"

Visar resultat 1 - 5 av 16 avhandlingar innehållade orden focal adhesion complex.

  1. 1. Regulation of the cytoskeleton and the adhesiveness of intestinal epithelial cells by leukotriene D4

    Författare :Ramin Massoumi; Institutionen för translationell medicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; oncology; Cytology; patologisk anatomi; Patologi allmän ; pathological anatomy; General pathology; PKC; vinculin; actin filament; focal adhesion; LTD4; integrin; cancerology; Cytologi; onkologi; cancer; Biochemistry; Metabolism; Biokemi; metabolism;

    Sammanfattning : Leukotrienes belong to a family of biologically active conjugated trienes that are formed from arachidonic acid via the 5-lipoxygenase pathway and are important mediators of inflammatory reactions. The CysLT1 receptor that specifically serves as receptor for leukotriene D4 (LTD4) has been identified as a G-protein coupled receptor. LÄS MER

  3. 2. Molecular Mechanisms of Action of Histidine-rich Glycoprotein in Angiogenesis Inhibition

    Författare :Chunsik Lee; Lena Claesson-Welsh; Jan Palmblad; Uppsala universitet; []
    Nyckelord :Cell and molecular biology; anti-angiogenesis; angiogenesis inhibitor; endothelial cell; histidine-rich glycoprotein; focal adhesion; tumor-associated macrophages; VEGF; MMP; Cell- och molekylärbiologi;

    Sammanfattning : Angiogenesis, de novo synthesis of blood vessels from the pre-existing vasculature, is required both during embryonic development and in pathophysiological conditions. In particular, tumor growth needs new capillary vessels in order to both deliver oxygen and nutrients and to remove toxin and metabolites. LÄS MER

  4. 3. Mechanisms of HAMLET-induced cancer cell death

    Författare :Sonja Aits; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; alpha-actinin; prohibitin; alpha-lactalbumin; HAMLET; cancer; cell death; autophagy; focal adhesions; c-Myc; hexokinase; glycolysis;

    Sammanfattning : HAMLET, a complex of α-lactalbumin and oleic acid, preferentially kills cancer cells and is also effective in vivo. HAMLET causes apoptosis but cells die even if this pathway is inhibited. Thus, the role of autophagy, an alternative cell death pathway, was examined. LÄS MER

  5. 4. Integrating bioinformatics and physiology to describe genetic effects in complex polygenic diseases

    Författare :Hemang Parikh; diabetes och endokrinologi Genomik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Insulin sensitivity; Type 2 diabetes mellitus; Skeletal muscle; Gene expressionprofiling; TXNIP; Maximal oxygen uptake; Type 1 fibers; NDUFB5; CPT1B; ATP5C1; AHNAK; CAST; Genome-wide association studies.;

    Sammanfattning : Type 2 diabetes mellitus (T2DM) results from interaction between genetic and environmental factors. The worldwide prevalence of T2DM is increasing rapidly due to reduction in physical activity, increase in dietary intake, and the aging of the population. LÄS MER

  7. 5. Nitric oxide in exhaled gas : studies on physiological regulation and measurements in infants and children

    Författare :Andreas Artlich; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :adrenaline; adrenoceptor; artificial ventilation; asthma; carbon dioxide; catecholamines; chemiluminescence; child; cilia; exhaled gas; focal adhesion complex; high frequency oscillatory ventilation; lung; mechanotransduction; newborn; nitric oxide; glucocorticosteroids; stretch;

    Sammanfattning : Nitric oxide (NO) is found in the exhaled gas of humans, starting from birth, and is increased in adult patients with bronchial asthma. This study assessed whether the measurement of NO in exhaled gas is technically feasible in infants and children. LÄS MER