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Visar resultat 1 - 5 av 28 avhandlingar som matchar ovanstående sökkriterier.
1. Transcriptional and post-transcriptional regulation of vascular smooth muscle cell phenotype - Implications for vascular disease states
Sammanfattning : As the world population is pushing toward 8 billion, cardiovascular diseases (CVD) remain the leading cause of death worldwide, representing 30% of all global deaths. A large body of work has recognized that smooth muscle cells (SMCs) surrounding the blood vessels play a prominent role in the development and progression of cardiovascular diseases. LÄS MER
2. Lipid storage and secretion. Studies on VLDL assembly and foam cell formation
Sammanfattning : This thesis deals with formation of two factors of upmost importance for the development of atherosclerosis: the triglyceride rich very low density lipoproteins 1 (VLDL1) and the lipid loaded macrophages ("foam cells"- characteristic features of the atherosclerotic lesion). Both these processes depend on the cellular accumulation of lipids. LÄS MER
3. Intracellular lipids and inflammatory activity in macrophage foam cells
Sammanfattning : Cardiovascular disease (CVD) is characterized by lipid accumulation and inflammation in arteries. The disease starts early in life with migration of monocytes into the arterial wall where they engulf entrapped lipoproteins and become macrophage foam cell. LÄS MER
4. Studies on receptors for modified LDL in human monocytes and macrophages : a link between diabetes and atherosclerosis?
Sammanfattning : Type 2 diabetes increases the risk for cardiovascular disease three- to fourfold. Because of the rise in diabetes prevalence there is a need for a better understanding of the link between diabetes and atherosclerosis. LÄS MER
5. Foam Core Materials for High Performance Sandwich Constructions: Preparation, Testing and Properties
Sammanfattning : The basic task for foams used as core materials in sandwich constructions is to separate the skin layers in order to enhance stiffness with little contribution to the total weight. However, modern design in sandwich technology require that core materials contribute to the perfor-mance with specific mechanical and physical properties. LÄS MER